Anrs, Emerging Infectious Diseases

This study tests a 12-week treatment with two oral drugs (sofosbuvir and daclatasvir) to cure active hepatitis C in children aged 6 to 17 in Cambodia. About 21,000 participants will take the pills and be monitored to see if the virus is gone 12 weeks after stopping treatment. The…

This early-stage trial tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and can boost the body's defenses against many types of coronaviruses. Participants receive one shot and are monitored for side effects and immu…

This study aims to eliminate hepatitis C among people who use drugs by combining mass screening with immediate treatment in community settings. About 3,400 participants in Paris, Marseille, Lyon, and Fort-de-France will be tested and treated, and will also invite their peers to j…

This study tests whether a structured exercise program can improve physical function and reduce disability in HIV-positive adults aged 50 and older in Côte d'Ivoire. Participants are randomly assigned to a supervised group exercise, a home-based program with phone support, or hea…