Anrs, Emerging Infectious Diseases

This study tests a new nasal spray COVID-19 booster vaccine (LVT-001) in healthy adults who have already received at least three mRNA COVID-19 shots. The goal is to see if the nasal spray is safe and boosts immunity better than a standard mRNA booster. The trial involves 238 part…

This study compares two different HIV medication combinations in people who have never taken HIV drugs before. The goal is to see if a newer drug called doravirine works just as well as the standard drug dolutegravir. About 610 adults with HIV-1 will take either doravirine or dol…

This study tests whether adding the drug adalimumab to standard TB meningitis treatment can reduce deaths in HIV patients. About 130 adults in Brazil, Mozambique, and Zambia will take part. The goal is to see if this approach is safe and improves survival within 3 months.

This study looks at whether giving a combination of two antiviral drugs (remdesivir plus nirmatrelvir/r) works better than the standard single drug for COVID-19 in people with weakened immune systems. It also tests if taking the medication for 10 days instead of 5 helps clear the…

This study follows up with 100 people who took part in the ANRS IPERGAY trial to see how HPV infections relate to anal cancer risk over 10 years. Researchers will use special tests to find HPV molecular signatures and check for high-grade lesions or cancer. The goal is to better …

This study follows 450 HIV patients who can naturally control the virus without taking antiretroviral therapy. Researchers want to understand how their immune systems keep the virus in check and why some eventually lose control. The goal is to learn more about HIV control and imm…