Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

Researchers are studying how heart arteries change after a blocked vessel is opened with a paclitaxel drug-coated balloon instead of a metal stent. The balloon delivers a drug to the artery wall and then is removed, leaving no permanent implant. About 150 adults who had this proc…

This trial compares two surgical approaches for people with pancreatic cancer in the left side of the pancreas. One method removes the spleen along with the tumor, which is standard practice. The other preserves the spleen, potentially reducing complications and avoiding lifelong…

This trial tests whether draining the gallbladder through an endoscope works better than the standard percutaneous approach for people with acute cholecystitis who are too sick for surgery. Researchers will randomly assign 212 participants to receive either endoscopic ultrasound-…

After left-sided pancreatic surgery, some patients develop painful or infected fluid collections that need drainage. This trial compares two standard approaches: placing a tube through the skin (percutaneous) versus using an endoscope to insert a stent (EUS-guided). The study wil…

This trial tests whether a newer balloon-expandable heart valve with intermediate sizes (Myval) is as safe as a standard self-expanding valve (Evolut) in people with severe aortic stenosis whose valve measurements fall in a 'borderline' range. About 600 participants will be rando…

This pilot study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard surgery and antibiotics is feasible for treating infected leg fractures. Fifty adults with confirmed or suspected infection will be randomly assigned to re…

This study tests whether a daily capsule of pasteurized Akkermansia muciniphila, a type of beneficial gut bacteria, can help adults recover after being treated for sepsis in the ICU. Fifty participants will take either the supplement or a placebo for 56 days. Researchers will che…

This study will test a new way to manage heart disease risk using a digital, nurse-led remote monitoring program. About 750 adults with heart conditions will use home devices and answer questionnaires. The goal is to see if this approach helps more patients reach their cholestero…

Ankle-foot orthoses (AFOs) help children with cerebral palsy walk better, but how they are prescribed and fitted varies widely. Researchers are testing a standardized protocol that guides healthcare professionals on AFO selection, training, and evaluation. The trial compares usua…

This study tests whether a 10-minute virtual reality (VR) relaxation session can lower stress in healthcare workers before they enter the operating room. About 80 volunteers will either use a VR headset or sit in a quiet room, and their heart rate and stress levels will be measur…

This study compares 3D-printed hand orthoses (braces) to traditional custom-made ones in 100 adults with chronic hand conditions from nerve, muscle, or bone issues. The goal is to see if the 3D-printed versions work just as well for daily activities, are more satisfying, and cost…

This study tests whether a newer 'splintless' jaw surgery is more accurate and safer than the standard method for treating obstructive sleep apnea. About 66 adults with moderate to severe sleep apnea who cannot use CPAP will be randomly assigned to one of the two surgeries. Resea…

This study tests whether a mobile app that tracks periods and teaches about menstrual health can improve quality of life for teens with painful or heavy periods. About 874 adolescents who have started their periods and speak Dutch, English, Turkish, or Moroccan-Arabic will use th…

This trial investigates how the severity of liver cirrhosis changes the way the body processes certain drugs. Adults with mild, moderate, or severe cirrhosis will receive a single low dose of five common drugs—caffeine, warfarin, esomeprazole, metoprolol, and midazolam—each used …

This study follows over a thousand people who have booked cosmetic injectable or surgical treatments, measuring changes in their psychological and social wellbeing using the FACE-Q questionnaire. A control group of people not receiving treatment provides a comparison. The goal is…

This study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…

This observational study will follow 500 children with hemophilia A who use non-factor therapy to prevent bleeding. Researchers want to understand why some children develop antibodies against factor VIII while others do not. By studying blood and stool samples over time, they hop…

This study looks at how often people develop speech or swallowing problems after a jaw-advancement surgery for obstructive sleep apnea. Researchers will measure nasality, speech, and swallowing in 28 adults before and after surgery at five different times. The goal is to better u…

This study tests how the antifungal drug fluconazole changes the gut microbiome and immune system in 50 healthy men aged 18-35. Participants take one pill daily for 14 days or receive no treatment. Researchers will compare stool and blood samples over 6 months to see if and how l…

This observational study will collect data from 15,000 heart surgery patients across many hospitals worldwide. Researchers will look at how anesthesia, heart-lung machines, and surgical techniques are used, and track patient outcomes like recovery time and complications. The goal…

This study tests a new way for people to share their health data from wearables like smartwatches to help improve heart disease prevention. Researchers want to see if this approach can include groups often left out of research, such as women and people with lower incomes. About 4…

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …

This study looks for proteins in the blood that could signal transfusion-related acute lung injury (TRALI), a rare but dangerous complication in ICU patients. Researchers will compare blood samples from 210 people, including ICU patients with and without lung injury, and healthy …