Which drainage method after pancreatic surgery is safer and better for patients?
NCT ID NCT07743762
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
After left-sided pancreatic surgery, some patients develop painful or infected fluid collections that need drainage. This trial compares two standard approaches: placing a tube through the skin (percutaneous) versus using an endoscope to insert a stent (EUS-guided). The study will enroll 96 adults and measure safety and quality of life over three months to see if one method offers advantages.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Two drainage procedures: EUS-guided placement of a plastic double pigtail stent versus percutaneous catheter drainage.
- What this could lead to
- If EUS-guided drainage proves safer or improves quality of life, it could become the preferred method for managing this common post-surgery complication.
- What could go wrong
- The trial is relatively small and early, and results may not apply to all patients. Both procedures carry risks like bleeding, infection, or stent/catheter problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 96 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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May 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ≥18 years * Symptomatic fluid collection following a left pancreatectomy requiring drainage according to the treatment team. Indications for drainage exists of: 1. Symptoms of abdominal pain and/or persistent nausea. 2. Suspected infection/ sepsis * Drainage of the fluid collection is feasible both endoscopically and percutaneously as per the treating team. NB: Preferably this is also assessed and supported by the expert panel, but this is NOT mandatory given the potential urgent nature of the intervention. The investigators expect that multidisciplinary consultation with both intervening specialties precedes the feasibility assessment. * No contraindications for either procedure. If the contraindication can be overcome safely, such as ascites for which prior abdominal drainage is needed, the patient can still be included. * No prior drainage attempts of the fluid collection. * In case of a previously intraoperatively placed drain, it should have been removed 5 days prior to fluid collection development. Exclusion Criteria: * \<18 years * The fluid collection is not endoscopically or percutaneously feasible per the expert panel's judgement or the treatment team in acute situations, for example due to collection location too far from the gastrointestinal tract. * Prior drainage attempts of the fluid collection. * Received an indwelling percutaneous drain intraoperatively. Intraoperatively placed drains are only permitted when at least removed 5 days prior to development of the fluid collection. * Permanent incapacitation of research participant, prior to clinical deterioration caused by the pancreatic fluid collection, without expectation of improvement as per the treatment team. * Unable to obtain informed consent by either patient or their legal representative.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Amsterdam UMC, location VUmc
Amsterdam, 1081 HV, Netherlands