THORACIC NEOPLASMS

This study tests a drug called teniposide in people with a hard-to-treat type of lung cancer that has spread and has not responded to standard treatments. The cancer must have a specific gene change (c-Myc-driven). The goal is to see if the drug can shrink tumors and control the …

This study tests a drug called tarlatamab as a maintenance treatment for people with limited-stage small cell lung cancer who cannot receive standard chemo-radiotherapy together. About 37 participants will receive tarlatamab infusions after initial treatment to see if it delays c…

This study tests whether mecapegfilgrastim can safely prevent moderate-to-severe low blood cell counts (myelosuppression) caused by chemotherapy and radiation in people with lung or esophageal cancer. About 30 adults aged 18-75 will receive the drug and be monitored for side effe…

This study tests whether a blood test (ctDNA) can help doctors decide if adding chemotherapy to the immunotherapy drug cemiplimab improves survival in people with advanced non-small cell lung cancer. About 63 adults with stage IV or stage IIIB/C lung cancer that has not been trea…

This study tests if a combination of three treatments—kyphoplasty (to stabilize the spine), radiofrequency ablation (to heat and destroy tumor tissue), and radiation therapy—can better relieve pain in adults with cancer that has spread to the middle or lower back. All 70 particip…

This study tests whether a diet rich in medium-chain triglycerides (MCTs) can help people recover faster after lung surgery. MCTs are fats that bypass the lymphatic system, which may reduce fluid buildup and speed healing. The trial will enroll 210 adults undergoing lung lobectom…

This study tests whether a specific nerve block (erector spinae block) can lower pain and the need for painkillers after lung surgery. About 70 adults having lung tumor removal will receive the block or standard care. Researchers will track pain scores and medication use for 24 h…