TESTICULAR CANCER

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety. About 10 participants will receive one of two dose lev…

This study tests whether adding the drug tarlatamab to standard radiation is safe and effective for cancers that have a protein called DLL3. About 30 adults with cancers like melanoma, lung cancer, or glioblastoma will receive the combination. The goal is to find the best timing …

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive cancers that have spread and no longer respond to other treatments. About 100 people will take part, and researchers will track whether tumors shrink and how long the benefit lasts. The goal i…

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancer that has come back or stopped responding to standard treatments. The drug works by helping the immune system attack cancer cells that have a specific marker called CLD…

This study tests whether taking a daily low-dose aspirin can prevent blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal is…

This study looks at two standard surgical techniques for removing a testicle due to suspected cancer. The goal is to see if one method causes less pain, less need for painkillers, and fewer complications after surgery. About 80 adults with testicular cancer will take part, and th…

This study tests if a drug called Pedmark (sodium thiosulfate) can reduce hearing loss in adults receiving cisplatin chemotherapy for cancers like testicular, head and neck, or thoracic cancer. About 25 participants will receive Pedmark alongside their standard chemo. The goal is…

This study tests whether a smartphone app that connects young adults (ages 18-40) with trained peer navigators can help them feel more in control of their health after finishing cancer treatment. About 138 people who had breast cancer, testicular cancer, lymphoma, or sarcoma will…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study compares two standard pain relief methods—spinal morphine and intravenous methadone—for men undergoing surgery for testicular cancer. The goal is to see which provides better pain control and reduces the need for additional opioids. About 142 participants will be enrol…

This study looks at how different treatments affect quality of life in men with good-prognosis metastatic testicular cancer. Some will have surgery (RPLND) and others will get chemotherapy. The goal is to see which approach causes fewer side effects and better long-term well-bein…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. Researchers will enroll 260 people …

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…