STOMACH NEOPLASMS

This study compares two surgical approaches for people with locally advanced stomach cancer: laparoscopic (keyhole) total gastrectomy versus open total gastrectomy. About 1,018 participants will be randomly assigned to one of the two procedures. The main goal is to see which meth…

This study tests whether combining targeted therapies with or without an immunotherapy drug can shrink advanced stomach tumors before surgery and improve long-term outcomes. About 50 adults with HER2-positive stomach cancer that cannot be removed right away will receive treatment…

This study compares two procedures for removing small precancerous growths (≤1 cm) in the stomach: argon plasma coagulation (APC), a simpler, non-contact method, and endoscopic mucosal resection (EMR), which cuts out the tissue. About 160 adults with low-grade dysplasia will be r…

This early-stage study tests an experimental drug called PF-08046050 in people with advanced solid tumors that have come back or not improved with standard treatments. The drug is designed to attach to cancer cells and kill them. The main goal is to check safety and find the righ…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer ce…

This early-stage trial tests a drug called sigvotatug vedotin, alone or with other medicines, in people with advanced solid tumors like lung, head and neck, or breast cancer. The goal is to find a safe dose and check for side effects. About 1,000 participants will join this study…

This study compares two surgeries—proximal gastrectomy and total gastrectomy—for people with locally advanced gastroesophageal junction cancer. About 120 adults aged 18 to 90 will be randomly assigned to one surgery type. The goal is to see which approach leads to better 3-year c…

This study tests whether adding the drug serplulimab to standard chemotherapy before and after surgery helps people with advanced stomach or gastroesophageal junction cancer. About 116 adults will be randomly assigned to receive either the combination or chemotherapy alone. The m…

This early-stage study tests a new drug called LY4337713 in people with advanced cancers (like pancreatic, breast, ovarian, or colorectal) that have high levels of a protein called FAP. The drug delivers radiation directly to cancer cells. The main goals are to check safety, find…

This study tests whether adding surgery and radiation to standard chemotherapy can improve outcomes for people with stomach cancer that has spread to specific lymph nodes in the back of the abdomen. About 54 participants will receive either standard treatment or a combination of …

This study tests a combination of two drugs—disitamab vedotin and tucatinib—for people with advanced breast or stomach cancers that have a protein called HER2. The goal is to see if the combo is safe and can shrink or control tumors. About 172 adults with these cancers who have a…

This study tests whether a combination of three drugs (adebrelimab, famitinib, and irinotecan) works better than irinotecan alone for people with advanced stomach cancer whose first treatment has stopped working. About 66 participants will be randomly assigned to one of the two g…

This study compares two ways to diagnose stomach cancer: using a small sample taken during an endoscopy (biopsy) versus using the whole tumor removed during surgery. The goal is to see if the biopsy alone can reliably determine the cancer type, grade, and key markers like HER-2 a…

This study collects blood, urine, tumor samples, and health information from up to 1,000 people with malignant mesothelioma and other cancers that express mesothelin. The goal is to build a tissue bank for future research, not to test a new treatment. Participants must be at leas…

This study aims to translate and adapt a Korean quality-of-life questionnaire into Spanish for patients who have had stomach cancer surgery. Researchers will enroll 505 adults who are at least one month past surgery and have no cancer recurrence. The goal is to create a reliable …

This study looks at how common Helicobacter pylori infection is in people newly diagnosed with stomach cancer in Martinique. Researchers will collect tumor samples, healthy tissue, and blood to build a biobank for future studies. The goal is to better understand why stomach cance…