STAGE IV NON-SMALL CELL LUNG CANCER
Clinical trials for STAGE IV NON-SMALL CELL LUNG CANCER explained in plain language.
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Lung cancer combo fails to outperform standard pill
Disease control CompletedThis study tested whether adding cetuximab (an antibody) to afatinib (a targeted pill) helps people with advanced EGFR-mutant lung cancer live longer. 174 patients were randomly assigned to receive either the combination or afatinib alone. The results showed no significant improv…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: PHASE2, PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 22, 2026 11:56 UTC
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New combo therapy shows promise for Hard-to-Treat lung cancer
Disease control CompletedThis early-phase study tested a new drug called ONO-7475 combined with the standard targeted therapy osimertinib in 78 people with advanced EGFR-mutated non-small cell lung cancer. The goal was to see if the combination is safe and tolerable. Participants had stage IIIB, IIIC, IV…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: PHASE1 • Sponsor: Ono Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Jun 18, 2026 11:52 UTC
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Radiation boost may help immunotherapy fight advanced lung cancer
Disease control CompletedThis study tested whether adding high-dose radiation to standard immunotherapy can better control advanced non-small cell lung cancer that has spread. 45 adults with stage IV cancer who were already on immunotherapy received targeted radiation to their tumors. The goal was to see…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: NA • Sponsor: Stanford University • Aim: Disease control
Last updated Jun 18, 2026 11:50 UTC
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New combo therapy shows promise against tough cancers
Disease control CompletedThis study tested a combination of two drugs—sEphB4-HSA and pembrolizumab—in 42 people with advanced non-small cell lung cancer or head & neck cancer that had spread or returned. The goal was to see if the combo could shrink tumors better than standard treatments. Participants ha…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: PHASE2 • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 15, 2026 19:08 UTC
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New combo therapy shows promise for brain metastases
Disease control CompletedThis early study tested combining the immunotherapy drug pembrolizumab with precise radiation (stereotactic radiosurgery) in 25 people with melanoma or lung cancer that had spread to the brain. The main goal was to check for serious side effects. Researchers also tracked how long…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: PHASE1 • Sponsor: Emory University • Aim: Disease control
Last updated Jun 15, 2026 18:55 UTC
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New drug combo shows promise for tough lung cancers
Disease control CompletedThis study tested a combination of two drugs, auranofin and sirolimus, in 29 people with advanced or recurrent lung cancer who had run out of standard treatment options. The goal was to find the best dose and see if the combo could slow or stop cancer growth. The trial focused on…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 11, 2026 12:09 UTC
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New combo therapy shows promise for hard-to-treat lung cancer
Disease control CompletedThis study tested a combination of a cancer vaccine (TG4010) and an immunotherapy drug (nivolumab) in 13 people with advanced non-small cell lung cancer who had already received other treatments. The goal was to see if the combination could shrink tumors or stop them from growing…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: PHASE2 • Sponsor: Megan Daly, MD • Aim: Disease control
Last updated Jun 08, 2026 13:11 UTC
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New radiation approach targets multiple tumors at once
Symptom relief CompletedThis early-stage study tested a high-precision radiation technique called SBRT in 42 people with breast, lung, or prostate cancer that had spread to several spots in the body. The main goal was to find the safest dose and check for side effects. Researchers aimed to deliver stron…
Matched conditions: STAGE IV NON-SMALL CELL LUNG CANCER
Phase: PHASE1 • Sponsor: NRG Oncology • Aim: Symptom relief
Last updated Jun 22, 2026 12:08 UTC