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New combo therapy targets hard-to-treat lung cancer

NCT ID NCT06525246

First seen Mar 19, 2026 · Last updated Apr 26, 2026 · Updated 1 time

Summary

This early-phase study tested a new drug (ONO-7475) combined with the standard targeted therapy osimertinib in 78 people with advanced EGFR-mutated non-small cell lung cancer that cannot be treated with radiation. The main goals were to check safety and find the right dose. Researchers also looked at how well the combination controlled the cancer and how long patients lived.

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Contacts and locations

Locations

  • Hyogo College Of Medicine College Hospital

    Nishinomiya, Hyōgo, Japan

  • Kanagawa Cancer Center

    Yokohama, Kanagawa, Japan

  • Kitasato University Hospital

    Sagamihara-shi, Kanagawa, Japan

  • Kobe City Medical Center General Hospital

    Kobe, Hyōgo, Japan

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, Japan

  • Nigata Cancer Center Hospital

    Niigata, Niigata, Japan

  • Osaka International Cancer Institute

    Osaka, Osaka, Japan

  • Osaka Medical and Pharmaceutical University Hospital

    Takatsuki, Osaka, Japan

  • Saitama Cancer Center

    Ina, Kitaadati-gun, Saitama, Japan

  • Shizuoka Cancer Center

    Nagaizumi-chō, Sunto-gun, Shizuoka, Japan

  • The Cancer Institute Hospital Of JFCR

    Koto-Ku, Tokyo, Japan

  • Tokyo Medical University Hospital

    Shinjuku-Ku, Tokyo, Japan

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, Kyoto, Japan

Conditions

Explore the condition pages connected to this study.