Ono Pharmaceutical Co., Ltd.

This phase 2 trial is testing the immunotherapy drug nivolumab in 23 people aged 1 year and older with advanced or recurrent rhabdoid tumors that have not responded to chemotherapy. The goal is to see if the drug can shrink tumors and improve survival. Participants receive nivolu…

This Phase 2 trial tests whether adding an experimental drug (ONO-4578) and an immunotherapy (Opdivo) to standard chemotherapy and bevacizumab can shrink tumors better than standard care alone in people with advanced colorectal cancer that is not MSI-high and has PD-L1 expression…

This phase 3 study tests an experimental drug called tirabrutinib for people with pemphigus, a rare autoimmune disease that causes painful blisters on skin and mucous membranes. The trial enrolls 34 adults whose disease is not well controlled by steroids. Participants receive eit…

This Phase 3 trial tests the drug cenobamate in 20 Japanese children aged 2 to 17 who have partial-onset seizures not controlled by current treatments. The main goal is to see if the drug is safe and tolerable. Participants take cenobamate tablets daily, with doses adjusted based…

This early-stage study tests a new drug called ONO-4685 in people with T cell lymphoma that has returned or not responded to prior treatments. The main goals are to check the drug's safety and find the best dose. About 217 adults will take part across multiple centers.

This phase 3 trial tests whether adding the drug sapablursen to standard treatment helps people with polycythemia vera, a blood disorder causing too many red blood cells. About 250 participants who currently need regular blood removal (phlebotomy) will receive either sapablursen …

This study tests a drug called ONO-4538 in 14 people with Richter's transformation, a rare and aggressive blood cancer that can develop from chronic lymphocytic leukemia. The main goal is to see if the drug shrinks tumors. Participants must have a specific type of Richter's and b…

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This early-phase study tests a new drug called ONO-7428 in about 60 adults with advanced solid tumors that have not responded to standard treatments. The main goal is to see if the drug is safe and tolerable, and to find the right dose. Participants will receive the drug and be m…

This study compares a new targeted drug, tirabrutinib, with a standard combination of two chemotherapy drugs (rituximab and temozolomide) in 132 people whose primary central nervous system lymphoma has returned or not responded to prior treatment. The main goal is to see which ap…

This study tests an experimental drug called ONO-2020 to see if it can safely reduce agitation in people with Alzheimer's disease dementia. About 90 participants in Japan will receive either the drug or a placebo daily for several weeks. Researchers will measure changes in agitat…

This study reviews medical records of 100 adults in Taiwan with resectable non-small cell lung cancer who received nivolumab (an immunotherapy) combined with chemotherapy before surgery. Researchers want to see if this approach helps shrink tumors completely and delays cancer ret…