Ono Pharmaceutical Co., Ltd.

This study tests a drug called tirabrutinib in people with primary central nervous system lymphoma (PCNSL), a rare cancer of the brain or spinal cord. The trial has two parts: one for patients whose cancer has come back or not responded to prior treatment, and another for newly d…

This Phase 2 trial tests an experimental drug called ONO-2808 in 92 people with multiple system atrophy (MSA), a rare and progressive brain disorder. The study compares three doses of the drug against a placebo to see if it is safe and can slow the disease. Participants take the …

This study tests whether adding an experimental drug (ONO-4578) to standard chemotherapy and immunotherapy can help people with advanced stomach cancer that cannot be removed by surgery. About 226 adults who have not had chemotherapy before will take part. The goal is to see if t…

This study tests a new medicine called ONO-2020 in 240 people with mild to moderate Alzheimer's disease. The goal is to see if it can safely improve memory and thinking skills. Participants will receive either the drug or a placebo for 26 weeks, and researchers will track side ef…

This Phase 2 trial tests whether a once-daily tablet called ONO-1110 can safely reduce bladder pain in people with Hunner type interstitial cystitis, a painful bladder condition. About 50 Japanese adults will receive either the drug or a placebo for 12 weeks. The main goal is to …

This study tests a new medicine called ONO-1110 in 100 Japanese adults with major depressive disorder. Participants receive either the drug or a placebo for 8 weeks. The main goal is to see if the drug reduces depression symptoms more than placebo.

This study tests an experimental drug called ONO-1110 to see if it can reduce symptoms of social anxiety disorder. About 100 Japanese adults with the condition will receive either the drug or a placebo for 12 weeks. The main goal is to measure changes in anxiety levels using a st…

This study tests an experimental drug called ONO-1110 to see if it can safely reduce pain in people with fibromyalgia. About 160 Japanese adults with fibromyalgia will receive either the drug or a placebo for 8 weeks. The main goal is to measure changes in average pain scores and…

This study tests an experimental drug called ONO-1110 to see if it can safely reduce pain in people with postherpetic neuralgia, a type of nerve pain that persists after a shingles infection. About 140 Japanese adults with pain lasting at least 3 months will receive either the dr…

This study looks at how the drug tirabrutinib moves through the body in people with different levels of liver function (mild, moderate, or severe liver problems) compared to healthy people. About 40 adults aged 18 to 75 will take part. The goal is to measure drug levels and safet…