STAGE IV LUNG CANCER AJCC V8
Clinical trials for STAGE IV LUNG CANCER AJCC V8 explained in plain language.
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New radioactive drug aims to hit bone tumors while sparing marrow
Disease control Not yet recruitingThis early-phase trial tests a new radioactive drug called tin-117m-DTPA in 24 people with prostate, breast, or lung cancer that has spread to the bones. The drug is designed to deliver low-level radiation directly to bone tumors while being gentler on the bone marrow. Researcher…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 22, 2026 11:58 UTC
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Light-Activated drug combo targets tough lung cancers in new trial
Disease control Not yet recruitingThis phase II trial tests a new treatment for people with advanced non-small cell lung cancer that has not responded to standard therapies. The treatment combines a light-activated drug (ASP-1929) with an immunotherapy drug (cemiplimab) to kill cancer cells. About 27 adults with …
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 18, 2026 11:48 UTC
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New hope for tough lung cancers: drug combo trial launches
Disease control Not yet recruitingThis study tests a new two-drug combination for people with advanced non-small cell lung cancer that has worsened after standard treatments like chemotherapy and immunotherapy. The drugs, SX-682 and atezolizumab, work together to help the immune system attack cancer cells. About …
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Jun 18, 2026 11:46 UTC
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New combo therapy targets hard-to-treat lung cancer mutation
Disease control Not yet recruitingThis study tests whether adding a cancer vaccine (CIMAVAX-EGF) to standard targeted drugs (sotorasib or adagrasib) can help control advanced lung cancer with a KRAS G12C mutation. About 29 adults with stage III or IV non-small cell lung cancer will receive the combination. The go…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 16, 2026 12:50 UTC
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Could a cheaper, Lower-Dose immunotherapy work just as well for advanced cancers?
Disease control Not yet recruitingThis study tests whether giving a lower dose of the immunotherapy drug nivolumab less often can still control advanced cancers that have spread or cannot be removed. About 50 adults with various cancers (like melanoma, lung, or kidney cancer) will receive the treatment. The goal …
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 15, 2026 18:56 UTC
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New drug combo aims to shrink Hard-to-Treat lung tumors
Disease control Not yet recruitingThis study tests two drugs, sacituzumab govitecan and ivonescimab, alone or together, in people with advanced non-small cell lung cancer that has specific gene changes. The goal is to see if the combination works better than either drug alone at shrinking tumors and delaying canc…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 15, 2026 18:55 UTC
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New imaging agent could help doctors see which lung tumors are still growing
Knowledge-focused Not yet recruitingThis early-phase trial is testing a new PET imaging agent called 64Cu-DOTA-pembrolizumab in 6 people with stage IV non-small cell lung cancer who are already on pembrolizumab and need radiation for some growing tumors. The goal is to see if the scan can safely tell the difference…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 12:01 UTC
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Spinal tap could spot brain metastases early in lung cancer patients
Knowledge-focused Not yet recruitingThis study tests whether a lumbar puncture (spinal tap) can find tumor DNA in the fluid around the brain and spine of people with stage III or IV non-small cell lung cancer. The goal is to see if this test can help predict which patients will develop brain metastases. About 40 pa…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:52 UTC