STAGE IIIC LUNG CANCER AJCC V8

This study looks at whether adding chemotherapy to immunotherapy (pembrolizumab) helps older adults (70+) with advanced non-small cell lung cancer live longer compared to immunotherapy alone. About 304 participants will receive either the combination or just immunotherapy. The go…

This study tests whether adding local treatments (like surgery or radiation) to the immunotherapy drug durvalumab can help control stage III lung cancer that has started to grow again after standard treatment. About 51 adults whose cancer has progressed after chemoradiation and d…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This study tests whether adding SX-682 to the immunotherapy drug pembrolizumab helps shrink tumors in people with advanced non-small cell lung cancer that has spread or returned. About 30 adults whose tumors have a certain protein (PD-L1) will receive both drugs. The goal is to s…

This study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…

This study tests whether the drug canakinumab can prevent lung cancer in people who have suspicious lung nodules that haven't gone away. About 50 participants will receive the drug to see if their nodules shrink or disappear, and to track how many develop lung cancer over time. T…

This study tests a smarter way to give radiation to people with lung cancer. Normally, the radiation plan is made before treatment starts, but tumors can shrink during treatment, which may expose healthy tissue to unnecessary radiation. In this study, the radiation plan is update…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, and also for their family caregivers. About 400 patient-caregiver pairs will take part. …

This study looks at how chemoradiation for locally advanced lung cancer affects the heart. Researchers will track heart injury and fitness in 100 patients, using each person's risk profile to tailor treatment and potentially reduce heart damage. The goal is to learn how to better…

This study looks at how the bacteria in your gut might influence stomach issues like diarrhea and colitis caused by certain cancer drugs (immune checkpoint inhibitors). Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or genito…