STAGE III PANCREATIC CANCER AJCC V8

This early-phase trial tests a new approach for people with pancreatic cancer that cannot be removed right away. Tiny nanoparticles called NBTXR3 are injected directly into the tumor and then activated by radiation therapy. The goal is to find a safe dose and see if this combinat…

This study tests whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) helps shrink tumors or slow cancer growth in people with advanced pancreatic cancer who have BRCA or PALB2 gene mutations. About 83 participants will receive either the chemo a…

This early-phase trial tests a combination of two drugs, calaspargase pegol-mknl and cobimetinib, in 15 people with advanced or metastatic pancreatic cancer. The goal is to find the safest dose and see if the combo can shrink tumors by cutting off their nutrient supply. It is a s…

This study tests whether a combination of two drugs, lenvatinib and pembrolizumab, can help keep advanced pancreatic cancer from getting worse. The trial involves 28 adults whose cancer cannot be removed by surgery and who have already responded to initial treatment. The goal is …

This early-phase trial tests a new drug called M6620 (berzosertib) combined with the chemotherapy irinotecan in people with advanced solid tumors that have spread or can't be removed. The goal is to find the safest dose and see if the combination can slow tumor growth. About 66 p…

This early-stage trial tests the safety of combining two drugs (olaparib and durvalumab) with radiation therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this triple approach can help control tumor growth. About 18…

This early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…

This early-stage trial tests a new drug called CA-4948 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) in people with pancreatic cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink …

This study tests a new method called sonoporation, which uses ultrasound and tiny gas bubbles to help chemotherapy drugs get into cancer cells more effectively. The trial includes 120 adults with advanced or hard-to-remove pancreatic cancer who are already receiving standard chem…

This early-phase study tests a new drug combination for people with advanced pancreatic cancer that has a specific marker (mesothelin). The treatment pairs a targeted chemotherapy with immunotherapy drugs and standard chemo to see if it's safe and what dose works best. About 74 a…