STAGE III LUNG CANCER AJCC V8

This early-stage trial is testing whether combining two drugs, carfilzomib and sotorasib, is safe for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. The study will involve 15 participants and aims to find the best dose and wat…

This early-phase trial is testing whether a personalized vaccine made from each patient's unique tumor proteins can safely boost the immune system against advanced breast cancer, melanoma, and lung cancer. The vaccine is given along with an immune-boosting drug (nivolumab) and an…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if the combination is safe and helps the immune system fight cancer more effectively. Ab…

This study looks at whether getting standard immunotherapy in the morning (before 11 am) or afternoon (after 12 pm) changes how well it fights advanced or metastatic solid tumors. Researchers think the body's internal clock (circadian rhythm) might affect immune activity. About 1…

This phase II trial tests whether adding diclofenac, a common anti-inflammatory painkiller, can help control advanced non-small cell lung cancer when immunotherapy alone starts to show signs of failing. About 20 adults whose cancer has progressed while on standard immunotherapy d…

This study tests a combination of two targeted drugs—sotorasib and trastuzumab deruxtecan—in people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the combo works at shrinking tumors. About 37 …

This study tests a new drug combination (GT103 plus pembrolizumab) for people with advanced or spreading non-small cell lung cancer that has a specific gene change called STK11. The goal is to see if the combo can shrink tumors or slow the cancer better than current options. Abou…

This study tests whether adding a precise, high-dose radiation treatment (SBRT) to the standard combination of radiation, chemotherapy, and immunotherapy can help people with locally advanced lung cancer live longer. About 474 adults whose cancer has spread to nearby lymph nodes …

This study tests whether adding local treatments like surgery or radiation to the immunotherapy drug durvalumab can help control stage III non-small cell lung cancer that has started to grow again after chemoradiation and durvalumab. About 51 adults will receive this combination.…

This study tests whether adding the experimental drug TRC102 to standard treatment (chemotherapy, radiation, and immunotherapy) can help shrink tumors and extend survival in people with stage III non-squamous lung cancer. TRC102 blocks cancer cells from repairing damage, making t…

This study tests whether the drug canakinumab can prevent lung cancer in 50 people who have suspicious lung nodules that haven't gone away. Participants receive the drug and are monitored for nodule shrinkage and cancer development. The goal is to see if this approach can stop lu…

This study tests whether a home-based breathing exercise program can help people who have finished treatment for early-stage lung cancer (stages I-III) breathe easier, feel less tired, and stay more active. About 100 survivors will do breathing exercises at home for several weeks…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, as well as for their family caregivers. About 400 patient-caregiver pairs will take part…

This study tests a communication tool that helps doctors and patients with non-small cell lung cancer work together on treatment decisions. About 100 patients and their doctors will use the tool during appointments to see if it improves how decisions are made and how satisfied pa…

This study looks at how chemoradiation for locally advanced lung cancer affects the heart. Researchers will track heart injury and fitness in 100 patients to see if tailoring radiation based on individual risk can reduce heart problems. The goal is to learn how to better protect …

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…

This study looks at how T cells change in people with advanced melanoma, lung, or other cancers during anti-PD-1 immunotherapy. Researchers will measure specific markers in blood samples to see if they can predict treatment response or resistance. The goal is to understand why so…

This study looks at two different ways surgeons cut blood vessels during lung cancer surgery. The goal is to see if tying off the vein first (instead of the artery) reduces the amount of tumor DNA released into the bloodstream. About 100 adults with early-stage lung cancer will h…