STAGE II RECTAL CANCER AJCC V8

This early-phase trial is testing whether people with stage II-III rectal cancer can safely avoid surgery by using chemotherapy followed by active surveillance (close monitoring) instead of immediate surgery. The goal is to preserve the rectum and avoid the need for a permanent c…

This early-phase study tests whether a short course of radiation followed by chemotherapy can shrink advanced rectal tumors enough to avoid surgery. About 25 people with stage II or III rectal cancer will receive this treatment. The goal is to preserve the rectum and improve qual…

This study tests a drug called zanidatamab given before surgery to people with HER2-positive colorectal cancer. The goal is to see if the drug can shrink or eliminate tumors, making surgery more effective. About 38 adults with early-stage cancer will take part, and researchers wi…

This study follows 430 people with rectal cancer (stages I–IV) to see how surgery affects their quality of life. Participants fill out questionnaires about their health and daily activities. The goal is to learn what matters most to patients after treatment, not to test a new dru…

This study is creating and testing a smartphone app to help people who have had colorectal cancer, along with their family caregivers, follow diet and exercise recommendations. The goal is to see if the app is easy to use and helpful. About 70 survivors and their caregivers will …

This study looks at whether a simple blood test can help doctors decide if rectal cancer patients can avoid surgery and keep their rectum. Researchers will measure tiny bits of tumor DNA in the blood (ctDNA) before, during, and after standard treatment in 50 adults with stage II …