STAGE II PROSTATE CANCER AJCC V8

This study tests whether a shorter course of higher-dose radiation (hypofractionated) works as well as or better than the standard longer course for men with prostate cancer who have had their prostate removed. About 186 men will be randomly assigned to one of the two radiation s…

This study was designed to test whether adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could improve outcomes for men with high-risk prostate cancer that hasn't spread. The goal was to see if the combination could eliminate cancer cells more…

This study tests whether a very low dose of apalutamide, a drug that blocks testosterone, can lower PSA levels in men with early-stage prostate cancer who are about to have their prostate removed. About 34 men will take the drug for 3-4 weeks before surgery. If PSA drops enough, …

This study tests whether adding a procedure called vesicopexy (lifting the bladder back to its normal position) to standard robotic prostate cancer surgery helps men regain bladder control faster. About 196 men with early-stage prostate cancer will be randomly assigned to receive…

This study compares two types of radiation therapy for men with early-stage prostate cancer that hasn't spread. One method places a tiny radioactive seed directly into the prostate, while the other delivers radiation from outside the body in five sessions. The goal is to see whic…

This study tests a lifestyle program called Watchful Living for Black and Hispanic men with early-stage prostate cancer who are on active surveillance, along with their partners. The program includes coaching calls and nutrition sessions to improve quality of life, physical activ…

This study looks at whether men with intermediate-risk prostate cancer can follow a Mediterranean diet for several weeks before their prostate removal surgery. The main goal is to see if this type of diet study is practical and well-tolerated. Researchers hope to learn how diet m…

This study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program helps improve quality of life, physical activity, diet, and partner support. About 6 couples will take part t…

This study looks at whether a DNA-based test can help predict which prostate cancer patients are more likely to have side effects from radiation therapy. About 208 men with early-stage prostate cancer will have their DNA tested for a marker linked to radiation sensitivity. Doctor…

This study looks at how daily stress, social support, and healthy habits like exercise and diet affect Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to track their activities and feelings. The goal is to understand how couples cop…

This study looks at how hormone therapy for prostate cancer affects the heart. Researchers will compare three treatment groups: radiation alone, radiation with leuprolide, and radiation with relugolix. The goal is to understand why some men develop heart problems and find ways to…