STAGE II PROSTATE CANCER AJCC V8

This study tests whether adding the drug apalutamide to usual hormone therapy and radiation can keep prostate cancer from spreading in men whose cancer reached lymph nodes after prostate removal surgery. About 586 men will be randomly assigned to get either standard treatment alo…

This study tests a type of internal radiation therapy (HDR-BT) that targets only the tumor in the prostate, rather than the whole gland. The goal is to control the cancer while reducing long-term urinary and sexual problems often caused by standard treatments. About 45 men with e…

This trial tests a procedure called TULSA that uses MRI-guided ultrasound to heat and destroy prostate tumors without cutting into the body. It is for men aged 45-80 with low-to-intermediate grade prostate cancer that has not spread. The goal is to see if this approach can contro…

This study tests whether taking high doses of vitamin D can help prevent bone loss in men aged 50 and older who are receiving hormone therapy (ADT) for prostate cancer. About 240 participants will receive either high-dose vitamin D or a placebo for one year. The goal is to see if…

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many men with low testosterone avoid TRT due to fears it might worsen their cancer, but this trial ai…

This study tests whether a special PET/MRI scan can accurately predict if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer will get the scan before surgery to remove the prostate. The goal is to see if the scan can identify who truly n…

This study tests a special tissue wrap placed on nerve bundles during prostate removal surgery. The goal is to see if it helps men recover erectile function and bladder control faster. About 25 men with localized prostate cancer will take part. The wrap is meant to protect nerves…

This study tests whether a newer, shorter radiation method (2 sessions) causes fewer side effects than the standard approach (5 sessions) for men with localized prostate cancer. About 144 participants will receive either the shorter or standard treatment, and their quality of lif…

This study tests whether a supervised golf exercise program can help prostate cancer survivors who are on hormone therapy improve their physical function, mental health, and quality of life. Twenty men aged 55-85 with little or no golf experience will take part. The program inclu…

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. Instead of using a single treatment plan, doctors adjust the radiation daily based on real-time MRI or CT scans to better target the tumor and avoid healthy tissue. The goal is to see if this …

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. By using real-time tracking to adjust the beam as the prostate moves, doctors hope to reduce urinary and bowel side effects. The study will enroll 80 men with early-stage prostate cancer to se…