SMALL LYMPHOCYTIC LYMPHOMA

This study tested a combination of two drugs, idelalisib and ofatumumab, in 27 adults with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal was to see how well the drugs worked together to shrink or control the cancer. Particip…

This study tested an oral drug called LOXO-305 (pirtobrutinib) in 803 people with chronic lymphocytic leukemia, small lymphocytic lymphoma, or other non-Hodgkin lymphomas whose cancer had stopped responding to or could not tolerate standard treatments. The goal was to find the be…

This study tested a new drug called BGB-10188, alone or combined with other cancer drugs, in 97 people with certain blood cancers (like lymphoma and leukemia) or advanced solid tumors. The main goals were to find safe doses and check for side effects. The trial was completed, but…

This study looked at 174 adults with blood cancers who received a stem cell transplant from an unrelated donor. Researchers compared different combinations of immune-suppressing drugs to find the best way to prevent graft-versus-host disease (GVHD), a serious complication where d…

This study tested a combination of two drugs, ofatumumab and lenalidomide, along with a steroid, in 45 people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal was to see if this treatment could make cancer disappear or shrink signifi…

This study tested whether the drug ibrutinib, combined with standard vaccines, can delay disease progression in people with early-stage, high-risk chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have no symptoms yet. Forty-two participants received ibru…

This early-phase study tested a combination of two drugs, acalabrutinib and obinutuzumab, in 69 people with chronic lymphocytic leukemia (CLL) or related blood cancers. The goal was to see if the combination was safe and could shrink or eliminate cancer. Participants included tho…

This study tested a drug called acalabrutinib in 48 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have a specific genetic change (deletion 17p). The goal was to see how well the drug controls the cancer. Participants took acalabrutinib pil…

This early-phase trial tested a new cell therapy called IOV-2001 in 7 people whose chronic lymphocytic leukemia or small lymphocytic lymphoma had stopped responding to standard treatments like ibrutinib. The therapy uses the patient's own immune cells, which are collected, proces…

This study tested a new combination treatment for people with non-Hodgkin lymphoma that had come back. The approach used three steps: first, freezing the tumor to kill cancer cells; second, injecting a personalized vaccine made from the patient's own immune cells; and third, givi…