SJOGREN'S SYNDROME

This early-stage study is testing a new cell therapy called YTS109 in 18 adults with severe autoimmune diseases like lupus and Sjogren's syndrome that have not responded to standard treatments. Participants receive a single infusion of these specially designed immune cells. The m…

This early-stage study tests a new medicine, SAR448501/DR-0201, in adults with lupus or rheumatoid arthritis. The goal is to find safe and tolerable doses by checking side effects and how the drug works in the body. About 62 participants will receive multiple doses and be followe…

This early-stage study tests a new treatment using a patient's own immune cells, modified to target and destroy faulty immune cells causing autoimmune diseases like lupus and scleroderma. The goal is to see if this 'reset' is safe and can control disease activity. About 20 adults…

This study tests whether tofacitinib, a drug already approved for rheumatoid arthritis, is safe for people with Sjogren's disease, an autoimmune condition causing dry eyes, dry mouth, and other symptoms. Sixty adults aged 18 to 75 with mild-to-moderate Sjogren's will take the ora…

This early-stage study tests a new drug, CLN-978, in 36 adults with active, moderate to severe Sjogren's disease. The main goal is to check safety and side effects. Researchers will also measure how the drug affects immune cells and stays in the body. Participants receive the dru…

This study tests an online health program that teaches diet and self-care habits to 200 adults with conditions like rheumatoid arthritis, lupus, or psoriatic arthritis. The goal is to see if the program can reduce fatigue and improve quality of life. Participants will complete su…

This study is testing whether a special PET scan called FAPI PET/CT can detect inflammation in people with Sjögren's syndrome, an autoimmune disease that causes dryness. Researchers will scan 60 adults and compare the results with blood tests and scans from tumor patients. The go…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study follows 300 people with Sjogren's disease (or symptoms) over time to learn how the condition starts and changes. Participants visit the NIH for exams, saliva and tear tests, and questionnaires. No new treatments are tested, but the findings may help develop better ther…

This study is a registry that will enroll up to 1,000 pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will collect information to identify risk factors for poor pregnancy outcomes. The goal…

This study looks at how natural cannabis compounds (like CBD and THC) affect immune cells from 100 people with chronic inflammatory diseases such as rheumatoid arthritis, lupus, and inflammatory bowel disease. Researchers will take a blood sample and expose the cells to different…

This study aims to learn more about diseases that affect the salivary glands, which can impact quality of life. Researchers will collect medical information, saliva, blood, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is …