SJOGREN'S SYNDROME

This study tests an experimental drug called dazodalibep in 651 people with Sjögren's syndrome who have moderate-to-severe disease activity. The goal is to see if the drug can reduce overall disease activity and improve symptoms like dryness, compared to a placebo. Participants w…

This early-stage study tests a new treatment called RD06-04, which uses a patient's own immune cells modified to target and destroy faulty B cells. It aims to control active autoimmune diseases like lupus, scleroderma, and Sjögren's syndrome. The main goal is to check safety, but…

This study tests the safety of tofacitinib, an oral drug, in 23 adults with mild-to-moderate Sjogren's syndrome, an autoimmune disease. Participants take the drug or a placebo for 168 days and undergo various tests like exams, biopsies, and questionnaires. The goal is to see if t…

This study looks at whether the Shingrix vaccine is safe and effective for people with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who have a higher risk of shingles. About 2,000 participants will receive the vaccine or no vaccine, and researchers will moni…

This study looks at immune system markers in the saliva and blood of 80 people with primary Sjögren's syndrome, a chronic disease causing dry eyes and mouth. Researchers will measure certain antibodies and enzyme activity before and after treatment for gum disease. The goal is to…

This study looks at whether giving people with inflammatory arthritis extra help—like a list of community resources, a community specialist, or a nurse navigator—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed a…

This study explores whether changes in gut bacteria can affect Sjogren's syndrome, an autoimmune disease causing dry eyes, dry mouth, and fatigue. Researchers will measure certain proteins in the blood that indicate gut leakage, and see if they relate to disease activity. The goa…