SEIZURES

This study compares a short course (6 months) versus a long course (2-3 years) of the seizure medicine levetiracetam in 604 adults with brain tumors who have been seizure-free for 6 months. The goal is to see if stopping the drug earlier can reduce side effects like drowsiness an…

This study tests whether levetiracetam, a seizure medication, can prevent epileptic seizures in adults over 40 with Down syndrome who also have Alzheimer's disease. 120 participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop se…

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive usual care. The goal i…

This study tests whether a non-invasive ultrasound treatment can reduce or stop seizure activity in people with a severe, ongoing seizure condition called status epilepticus that hasn't improved with standard medications. Ten participants will receive a 10-minute focused ultrasou…

This study aims to make it easier for paramedics to stop seizures in children by using age-based doses of the medicine midazolam instead of calculating doses based on weight. About 6,700 children who are actively seizing when paramedics arrive will be included. The goal is to see…

This study aims to better understand epilepsy and find new ways to help people whose seizures don't improve with medication. Researchers will screen up to 1,000 adults and children aged 8 and older using tests like brain scans and EEGs. The goal is to identify participants who ma…

This study follows 1,000 people with certain genetic changes linked to brain development issues like autism, intellectual disability, and seizures. Researchers collect medical records, school reports, and test results to see how these genes affect thinking, movement, and behavior…

This study is observing 1,400 newborns in China who have had a seizure to find out how often it happens and how it affects their development. Researchers will use EEG to record brain activity and follow the babies over time. The goal is to better understand neonatal seizures, not…

This study looks at how a drug called scopolamine changes brain activity related to memory. Researchers will test 60 adults with epilepsy who are already having brain surgery for seizure monitoring. Participants will do memory tasks after receiving either the drug or a saltwater …

This study is testing a low-cost, ear-worn device that can detect and predict seizures in real time. About 40 adults with epilepsy will wear the device while staying in the hospital for standard monitoring. The goal is to see how accurately the device can spot seizures and even p…

This study looks at what causes oxygen toxicity in scuba divers. Researchers want to see how things like breathing muscle training, lack of sleep, certain medications, and carbon dioxide affect risk. 62 healthy divers aged 18-45 will exercise underwater and in dry conditions to m…

This study looks at the genes of 2,000 newborns and infants who have seizures within their first year of life. By understanding their genetic makeup, doctors hope to find better, personalized treatments. The goal is to see which gene changes are common and how well different trea…

This study aims to find genetic heart problems that might explain why some people with epilepsy die suddenly. Researchers will test 600 adults aged 18-50 with epilepsy, seizures, or related events, plus their blood relatives. They use advanced gene sequencing to look for known he…

This study aims to understand how the brain creates the feeling of wanting to move. Researchers will use safe, non-invasive techniques like brain stimulation and EEG to measure brain activity in 30 people—both healthy volunteers and patients with psychogenic movement disorders or…