SEDATION AND ANALGESIA

This study looks at two ways to manage sedation in COPD patients who need a breathing machine (ventilator). One group gets no sedation at all, while the other has their sedation paused every day. The goal is to see which approach helps patients spend more days off the ventilator …

This study compares two common painkillers, fentanyl and hydromorphone, in patients who need a breathing machine in the ICU. The goal is to see if one leads to better outcomes, like using less pain medication overall and improving recovery. About 300 adults will take part, and th…

This study compares two sedatives, remimazolam and midazolam, in 440 critically ill adults on breathing machines in the ICU. The goal is to see if remimazolam helps patients come off the ventilator faster. Participants will be randomly assigned to receive one of the two drugs, an…

This study tests whether adding non-opioid pain medicines like acetaminophen (Tylenol) and ketorolac (Toradol) can improve pain control and reduce the need for strong opioids in children on breathing machines. About 644 children aged 2 months to 17 years will be randomly assigned…

This study tests whether interventional radiologists can safely give deep sedation (using ketamine) for procedures that normally require general anesthesia. The goal is to see if this approach works well and is safe, with anesthesiologists on standby if needed. About 40 adults wi…

This study looks at how cannabis use affects the amount of sedation medicine needed during wisdom tooth removal. Researchers will compare cannabis users and non-users to see differences in drug doses, heart rate, blood pressure, and breathing. The goal is to help doctors provide …

This study looks at how painkillers and sedatives are given to very sick patients on a life support machine called ECMO. The goal is to understand current practices and then work with patients, families, and staff to create a better, safer sedation plan. About 120 adults in UK in…

This study looks at how two common anesthesia drugs affect brain activity and pain signals in 20 adults undergoing a procedure called ERCP. Researchers will use EEG and pain monitors to gather data. The goal is to better understand how these drugs work, not to test a new treatmen…

This study looks at how often pain occurs in intensive care patients who are on breathing machines. Researchers will check pain levels using special scales and see if pain is linked to longer time on the ventilator or higher death rates. The goal is to better understand and manag…