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New sedative may cut ventilator time for ICU patients

NCT ID NCT05160987

Symptom relief Sponsor: Zhujiang Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two sedatives—remimazolam and midazolam—in 440 critically ill patients on breathing machines. The goal is to see if remimazolam helps patients come off the ventilator faster. Participants are randomly assigned to one drug, and researchers track how long they need mechanical ventilation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remimazolam
What this could lead to
If it works, this could mean ICU patients on ventilators need less time on breathing machines, potentially reducing complications and speeding recovery.
What could go wrong
This is a mid-stage trial, so results may not confirm benefit. Sedation drugs can cause side effects like low blood pressure or breathing issues, and individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 440 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2022

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Critical ill patients that are mechanically ventilated within the first 48h of admission to the ICU and who would remain in the ICU for over 72h were enrolled in this study. 2. Age 18-80 years. 3. Voluntary informed consent. Exclusion Criteria: 1. Surgical treatment is performed within 24 hours. 2. Craniocerebral injury, post neurosurgery, non drug coma, mental illness or peripheral neuropathy. 3. Heart rates are less than 50 beats / min or severe atrioventricular block without pacemaker support. 4. The mean arterial pressure is less than 55 mmHg even though fluids and vasoactive drugs are administrated. 5. Patients who are known or suspected allergy to benzodiazepines, propofol, dexmedetomidine or opioids. 6. History of alcohol and drug abuse. 7. End stages of lung diseases, such as pulmonary fibrosis, lung damage, etc. 8. Pregnancy.

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sedation and analgesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University

    RECRUITING

    Guangzhou, Guangdong, 510282, China

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