SARCOIDOSIS

This Phase 3 trial compares a low-dose combination of prednisone and methotrexate to standard high-dose prednisone for people with active cardiac sarcoidosis. Researchers hope the combo works just as well but causes fewer side effects and improves quality of life. The study plans…

This study looks at whether vitamin D supplements can help people with sarcoidosis who have low vitamin D levels. Researchers will give some participants vitamin D2 and others a placebo, then measure changes in lung function and quality of life. The goal is to see if correcting v…

This study is testing a new imaging technique called full-field optical coherence tomography (FFOCT) to examine small lung biopsy samples taken during bronchoscopy. Researchers want to see if FFOCT can provide results that match standard lab analysis, potentially allowing faster …

This study explores a new blood test that looks for DNA fragments from damaged heart cells to detect active heart inflammation in people with sarcoidosis. Researchers will compare results from 120 participants, including healthy volunteers and those with known heart conditions. I…

This study tests whether an 8-week online Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in people with sarcoidosis. One group does MBSR with weekly sessions and daily journaling; the other joins a monthly virtual support group. Rese…

This study looks at two different schedules for lowering steroid doses in people with stable sarcoidosis. The goal is to reduce long-term side effects like diabetes and bone loss while keeping the disease under control. About 100 adults on a stable low dose of prednisolone will b…

This study is creating a registry and biobank for up to 1,000 people with interstitial lung diseases, including sarcoidosis and pulmonary fibrosis. Researchers will collect medical data and biological samples over time to help future studies. The goal is to better understand thes…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study looks for new genes and blood markers linked to arrhythmogenic cardiomyopathy, a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1,000 people with the condition or their family members from the US and UK. By collecting medical data…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study looks at why sarcoidosis affects people differently—some get better, others develop long-term lung damage. Researchers will analyze genes, immune cells, and gut bacteria from 5,000 participants, including healthy volunteers. The goal is to find markers that predict dis…

This study is building a large, long-term database of experiences from people living with sarcoidosis. Participants complete surveys about their symptoms, diagnosis, treatments, and daily life, and can share their medical records. The goal is to map the natural course of the dise…

This study looks at how immune cells work in lung cancer, sarcoidosis, and COPD. Researchers want to understand why some people don't respond to immunotherapy. They will study samples from 425 people, including patients and healthy volunteers, to find clues for better, more perso…

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…