SAFETY ISSUES

This early-phase study tested an oral drug called ICM20 in 13 adults with Chagas disease. The main goal was to check for side effects and see how many people stayed on the drug for 28 and 60 days. The study was not designed to cure the disease, but to gather safety information fo…

This early-stage study tested a vaginal insert containing two drugs (tenofovir alafenamide and elvitegravir) to prevent HIV and herpes (HSV) infection. Sixty-eight healthy women used the insert daily for 3 days, then every other day for 14 days. The main goal was to check safety …

This study looked at whether taking ibuprofen for eight days after hip or knee replacement is safe. About 2904 adults took part. Researchers tracked serious problems like heart attack, stroke, bleeding, or kidney failure for 90 days after surgery.

This study tested a lean leadership training program for head nurses at Mansoura Children Hospital. The goal was to see if the training could improve how head nurses lead and make the workplace safer for staff nurses. About 200 head nurses and staff nurses took part. The study me…

This early-stage study tested a vaginal ring that releases two drugs (dapivirine and levonorgestrel) in 40 healthy HIV-negative women. The goal was to measure how the body absorbs the drugs and check for safety and bleeding changes over 90 days. Results will help design future st…

This study tested if wearing a special facemask during upper endoscopy (a scope down the throat) lowers the amount of tiny particles released into the air. 57 adults having elective procedures took part, some with a mask and some without. The goal was to see if masks can help pro…

This study tested whether a cell-free fat tissue product is safe to inject under the skin. 38 healthy adults received the product on one arm and a saltwater solution on the other. Researchers monitored for side effects like swelling, pain, or allergic reactions. The goal was only…