Safety issues

This early-phase trial tests whether injecting special donor cells (E-CEL UVEC) into the shoulder during rotator cuff surgery is safe and might improve healing. Twenty adults aged 45-70 with full-thickness tears will receive the cells at the repair site. The main goal is to check…

This trial tests whether proglumide, an older drug that blocks a specific receptor, can safely reduce pain and slow or reverse the scarring seen in chronic pancreatitis. The study includes adults with confirmed chronic pancreatitis and compares proglumide against a placebo over 1…

This study looks at switching kidney or liver transplant patients with chronic hepatitis B to a drug called tenofovir alafenamide (TAF). The goal is to see if TAF is safer for the kidneys, controls the virus well, and is easier for patients to stick with. The study involves 52 ad…

This early-stage trial is testing a new drug called RG002C0106 in 30 healthy adults to see if it is safe and how the body processes it. The drug uses RNA interference to silence a gene involved in the immune system's complement pathway. The study is randomized and placebo-control…

This study tests a program called ACTFAST that trains doctors and nurses at three children's trauma centers to talk with families about safe firearm storage. The goal is to help prevent gun injuries in kids. Researchers will survey parents, teens, and clinicians to see if the tra…

This study tests a program called ACTFAST in three trauma centers. The program screens injured patients for firearm access, offers brief counseling on safe storage, and connects them to community resources. Researchers will track whether the program increases safe storage practic…