RETINOBLASTOMA

This study aims to help children with retinoblastoma, a rare eye cancer, in low-income African countries. The goal is to improve survival rates by promoting early diagnosis and following a set of treatment guidelines. The study will enroll 3,000 children and track how well the gu…

This study tests a chemotherapy-loaded patch (chemoplaque) placed on the eye to treat advanced or recurrent retinoblastoma in children under 8. The goal is to save the eye from removal. Researchers will check safety and how well the treatment works.

This study tests two treatment strategies for children with retinoblastoma, a rare eye cancer. One part compares two types of chemotherapy given directly into the eye artery to see which better saves the eye. The other part looks at how well vision is preserved with standard IV c…

This early-phase trial tests a new treatment called GPC2 CAR T cells for children with advanced neuroblastoma or retinoblastoma that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to better recognize and at…

This study collects extra blood, tissue, and urine samples from children and adults with childhood cancers like leukemia and brain tumors. The goal is to create a large repository for researchers to study the biology of these cancers. No extra procedures are needed—samples are ta…

This study looks at the genes of 100 people with retinoblastoma, a rare eye cancer in children. Researchers want to understand how changes in the RB1 gene cause cancer and affect treatment. Participants give a blood or saliva sample for genetic testing. The goal is to learn more …

This study follows 900 people who had retinoblastoma as children, along with their family members, to learn about long-term health outcomes. Researchers will collect vision tests, tissue and saliva samples, and surveys over time. The goal is to understand what causes the disease,…

This study collects fluid from the front of the eye and tumor tissue from children with retinoblastoma, a rare eye cancer. Researchers aim to find genetic markers that can predict whether the eye can be saved with treatment. Up to 800 children treated at Children's Hospital Los A…

This research study aims to discover new genes that may increase the risk of childhood cancer. Researchers will collect blood samples and health information from 1,500 people in families where cancer clusters. The goal is to build a registry and sample bank to help future diagnos…

This study looks at whether a special MRI scan can predict how well children with retinoblastoma (a rare eye cancer) will respond to chemotherapy delivered directly to the eye. Researchers will follow 60 children for 18 months after treatment to see if the MRI findings match the …