PREDIABETIC STATE

This study tests whether applying heat pads to the legs for 90 minutes daily can improve blood sugar control, muscle health, and physical function in older adults with prediabetes. Researchers will compare heat therapy to high-intensity interval training (HIIT) in 54 sedentary pe…

This study is testing whether exercising in the afternoon is better than exercising in the morning for improving blood sugar control in people with prediabetes. Researchers will ask 48 participants to do high-intensity interval training three times a week for 12 weeks, either in …

This study tests whether taking a daily zinc supplement for one year can lower blood sugar and HbA1c levels in people with prediabetes. Researchers will compare zinc to a placebo in 200 Amish adults aged 18-80. The goal is to see if zinc can help control blood sugar and prevent t…

This study follows overweight and obese adults aged 45-65 to see if a tailored program of counseling, supervised exercise, and digital tools helps them lose weight and improve heart health over 18 months. Participants are compared to a group that only gets general written advice.…

This study looks at whether a type of talk therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will either get CBT-I or general health education. The goal is to see if improving sleep can r…

This study looks at whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program helps people at risk for prediabetes stay engaged. About 20 adults in Los Angeles will take part. The goal is to see if this approach is practical and acceptable, not …

This study looks at whether metformin, a medicine used for diabetes, can lower the risk of death, heart attacks, or strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will be followed over time. The goal is to see if…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This study follows 850 adults with normal cognition or mild memory issues to identify early risk factors for Alzheimer's disease. Researchers will track changes in memory, brain scans, and spinal fluid markers over time, with a special focus on how blood sugar and insulin problem…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study looks at how resistance training (like lifting weights) affects fat breakdown in obese postmenopausal women who also have prediabetes. Researchers want to see if this type of exercise can improve how the body uses fat, which might help prevent type 2 diabetes. The stud…