POSTTRAUMATIC STRESS DISORDER (PTSD)

This study tests a new therapy called A-EMDR, where people use eye movements on their own to help with PTSD and substance use. Researchers want to see if it reduces PTSD symptoms and drug or alcohol use over 4 weeks. The study involves 24 adults and compares A-EMDR to standard ca…

This study tests whether a fast-paced form of PTSD therapy, called Massed Prolonged Exposure (M-PE), can help adults in a substance use treatment program. About 168 participants will either receive M-PE or their usual trauma care. Researchers will track changes in PTSD symptoms, …

This study tests whether a medication called RE03 (dexmedetomidine), already used in hospitals, can improve sleep quality in people with PTSD who struggle with sleep disturbances like nightmares. About 24 adults with PTSD will receive either the drug or a placebo in a random orde…

This study tests a two-week intensive outpatient treatment for adults with PTSD. Up to 42 participants will receive daily therapy and be followed for 12 weeks. Researchers will measure changes in trauma symptoms and daily functioning using questionnaires and interviews.

This study compares two types of talk therapy for adults with anxiety disorders (GAD, social anxiety, or PTSD). One is the standard cognitive-behavioral therapy (CBT), and the other is a newer approach called metacognitive therapy (MCT), which focuses on how people think about th…

This study tests whether a 6-week mindfulness program (MBSR) can reduce PTSD symptoms and improve quality of life in people who have been in a road traffic accident. About 110 adults aged 18-60 with PTSD will be randomly assigned to either MBSR or standard care. Researchers will …

This study tests a therapy program called HOPE for adults who have both opioid use disorder and PTSD. Participants must already be on stable medication for opioid use (like Suboxone or methadone) and will attend 10-12 weeks of therapy sessions. The goal is to see if HOPE reduces …

This study tests whether methylphenidate, a drug often used for ADHD, can improve memory, concentration, and daily functioning in veterans with PTSD. About 70 veterans will take turns receiving the drug or a placebo over 20 weeks, with each phase lasting 4-5 weeks. The goal is to…

This study compares a single dose of ayahuasca (a plant-based psychedelic) or esketamine (a fast-acting antidepressant) in 10 adults with posttraumatic stress disorder (PTSD). Participants receive one oral dose in a double-blind, randomized setup, and researchers track PTSD sympt…

This study tests whether adding a brief crisis coping strategy (Crisis Response Planning) to a standard PTSD talk therapy (Cognitive Processing Therapy) can lower suicidal thoughts and behaviors in veterans. About 190 active-duty service members and veterans with PTSD and recent …

This study tests whether a special type of talk therapy for PTSD, delivered by video at syringe service programs, is practical and helpful for adults who are also taking medication for opioid use disorder. Researchers want to see if the therapy reduces PTSD symptoms and helps par…

This study looks at whether short-term changes in the immune system can alter how people with PTSD process fear. About 288 adults who have experienced trauma will receive either a typhoid vaccine or a placebo. Researchers will measure their physical responses to sounds and use qu…

This study aims to see how well a new survey (CIDI 5.0) can identify people who have had depression, anxiety, or PTSD at some point in their lives. Researchers will compare the survey results to a detailed clinical interview, which is the current gold standard. About 300 adults i…

This study looks at how the brain works in people with PTSD, focusing on why they feel constantly on edge. Researchers will test a gentle brain stimulation technique called tACS to see if it can calm overactive fear circuits. The goal is to understand the brain changes behind PTS…

This study looks at how the brain works differently in people with PTSD, especially in areas that process senses and emotions. Researchers will use brain scans and EEG to measure activity, then test a gentle electrical stimulation method called tACS to see if it can reduce feelin…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…