POSTPARTUM DEPRESSION

This study tested a medicine called SAGE-547 given as a 60-hour IV drip to help women with moderate to severe postpartum depression. 108 women took part. The goal was to see if the drug could quickly lower depression scores compared to a placebo. Results showed improvement in dep…

This study tested a special education program for 88 pregnant women to see if it could lower depression after childbirth and strengthen the bond between mother and baby. The program was based on a caring model that focuses on the mother's feelings and needs. Results suggest that …

This study tested whether a 12-session parenting group therapy called CARE is helpful and doable for new parents experiencing postpartum depression or anxiety. 17 parents with babies 3-12 months old took part. The goal was to see if the program could improve mental health, reduce…

This study tested an experimental drug called SAGE-547 in 138 women with severe postpartum depression. The drug was given as a 60-hour IV infusion to see if it could quickly reduce depression symptoms compared to a placebo. The goal was to help new mothers feel better without lon…

This study looked at ways to reduce pain in women who had severe perineal tears during childbirth. 67 women were given either a placebo, a low dose of ketamine plus morphine, or morphine alone. The goal was to see which option worked best for pain one week after delivery.

This study tested whether a single injection of RE104 can reduce symptoms of moderate-to-severe postpartum depression in new mothers. 84 women who were up to 15 months postpartum and not on other depression medications took part. The goal was to see if the higher dose worked bett…

This study tested whether a mindfulness-based program (MBCT) could help pregnant women who are feeling stressed, anxious, or down. 84 at-risk women participated, learning mindfulness skills to support their mental health during pregnancy and after childbirth. The goal was to see …

This study tested an oral drug called NORA520 in 93 women with severe postpartum depression. Participants took the drug or a placebo for 3 days. Researchers measured how well it reduced depression symptoms and checked for side effects. The goal was to see if NORA520 is a safe and…

This study tested a program called the Pregnant Moms' Empowerment Program (PMEP) for pregnant women who had experienced intimate partner violence in the past year. About 230 women took part in either the PMEP or a general discussion group. The program aimed to reduce stress, depr…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for pregnant women with depression. PIC combines bright light therapy, sleep schedule changes, and sleep stabilization. 120 pregnant women with major depression were randomly assigned to rec…

This early study tested an experimental drug called SAGE-547 in 4 women with severe postpartum depression. The main goal was to check if the drug is safe and how the body processes it. Results are limited due to the very small number of participants, but the study helps lay the g…

This study looked at whether the drug ZULRESSO (brexanolone) can be safely given to women with postpartum depression in their own homes instead of a clinic. Fifty-two women took part, and researchers tracked side effects and whether the safety rules were followed. The goal was to…

This study tested whether a virtual group session for Spanish-speaking mothers of newborns could help them learn about postpartum depression and connect with support resources. 26 mothers participated in a single group session alongside their baby's regular checkup. The goal was …

This study followed 300 pregnant women with and without mood disorder histories to uncover why some develop postpartum depression or psychosis. Researchers collected genetic, hormonal, and environmental data like sleep and stress to identify risk factors. The goal is to eventuall…

This study tested whether adding psychodramatic role-playing to standard childbirth preparation classes could lower the risk of postpartum depression and improve self-efficacy and social support in first-time mothers. 57 pregnant women participated, with one group receiving stand…

This study looked at whether the drop in pregnancy hormones after childbirth triggers mood problems in women who have had postpartum depression before. Researchers created a temporary hormone environment similar to pregnancy and then stopped it to see how mood changed. 74 women w…

This study tested a free chatbot called Rosie that answers pregnant women and new moms' health questions instantly using verified sources. 400 minority women aged 14+ who were pregnant or had an infant under 6 months used the chatbot on their phone or computer. The goal was to se…

This study tested a program to help Black mothers after childbirth who are at high risk for health problems. Participants received a helpful pamphlet and a patient navigator they could contact for 30 days. The goal was to see if this support reduces emergency room visits and help…