Postpartum depression

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study investigates whether taking vitamin B6 supplements during late pregnancy and after childbirth can help prevent depression. Pregnant women without a history of mental health conditions take either vitamin B6 or a placebo from around 24-28 weeks of pregnancy until six we…

This study looks at whether the ROSE program, which has been shown to prevent about half of postpartum depression cases in women at higher risk, can work for all new mothers. Researchers will enroll 2,320 pregnant women from a large health system in Detroit to see if offering the…

This study tests whether an online sleep improvement program for pregnant women can reduce stress and prevent postpartum depression and anxiety. Researchers will enroll 114 women early in pregnancy and track their sleep, stress hormones, and mood for months after birth. The progr…

This study tests whether a midwife-led digital follow-up program can reduce postpartum depression and improve breastfeeding success in women who had a C-section. About 104 women will either get the digital program or standard care. The goal is to see if extra support through phon…

This study follows 200 people with postpartum depression who are starting zuranolone (Zurzuvae). Researchers will use online surveys to track symptom changes at 15, 45, and 90 days. The goal is to see how symptoms improve in everyday conditions, not in a controlled lab setting.

This study tests a new type of talk therapy called Engage & Connect for mothers with postpartum depression. The therapy focuses on helping moms plan and do rewarding social activities to reduce feelings of isolation. Sixty participants will receive either this new therapy or a st…

This trial tests whether a non-invasive brain-stimulation device called transcranial direct current stimulation (tDCS) can reduce symptoms of moderate-to-severe depression in pregnant people. Participants use the device at home for 15 sessions over three weeks, while a comparison…

This study tests whether providing doula support and care coordination to parents of preterm babies in the NICU can reduce stress, depression, and anxiety. Twenty English-speaking mothers of babies born before 34 weeks are being recruited. The doula helps connect families to ment…

This study tests a mindfulness program called 'Mindful with your Baby' for mothers with babies aged 5-9 months who have postpartum depression, anxiety, or stress. The program includes 8 group sessions where mothers practice mindfulness with their babies. Researchers will measure …

This study tests whether spending more than 2 days in a kangaroo mother care (KMC) ward—where mothers hold their low birthweight babies skin-to-skin and get breastfeeding support—can lower the risk of postpartum depression. About 1,900 mothers and their preterm infants in Zambia …

Researchers at the University of Idaho are studying whether an 8-week mindfulness program focused on self-compassion or 8 weeks of vitamin D supplements can reduce stress in mothers of preterm infants. The trial enrolls 500 mothers and measures stress hormones, self-compassion, a…

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This study tests a computer tool that uses artificial intelligence to alert doctors when a pregnant patient may be at high risk for postpartum depression. The tool gives doctors a risk score and suggests steps like referrals or educational materials. Researchers will ask 160 preg…

This study follows 600 pregnant women with gestational diabetes to see how depression and diabetes affect each other during pregnancy and after birth. Some participants will receive short health education videos about diet, exercise, and support. The goal is to understand the con…