POSTPARTUM DEPRESSION

This study tested a drug called SAGE-547 (brexanolone) given as a 60-hour intravenous infusion to women with moderate to severe postpartum depression. 108 women participated, and the main goal was to see if the drug reduced depression symptoms compared to a placebo. The trial mea…

This study tested an experimental oral drug called NORA520 in 93 women with severe postpartum depression. Participants took the drug or a placebo for 3 days. Researchers measured how well it reduced depression symptoms, checked for side effects, and looked at how much of the drug…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression were randomly assigned to receive either usual care (medication or therapy) or PIC plus usual c…

This study looked at whether the drug ZULRESSO (brexanolone) can be safely used at home to treat postpartum depression. Fifty-two women with postpartum depression took part. The main goal was to see if any side effects caused the treatment to be stopped or interrupted. The study …

This study looked at ways to reduce pain in women who had severe tears during childbirth. 67 women received either a placebo, a low dose of ketamine plus morphine, or morphine alone. The goal was to see which option worked best for pain one week after delivery.

This study tested a short educational program for pregnant women to see if it could lower the risk of postpartum depression and strengthen the bond between mother and baby. 88 women in their 20th to 35th week of pregnancy took part. The program taught caring techniques based on t…

This study tested whether a 12-session parenting group therapy, called the Connecting and Reflecting Experience (CARE) program, is helpful and doable for new parents struggling with postpartum depression or anxiety. Seventeen parents of babies aged 3 to 12 months took part. The g…

This study tested a single injection of RE104 in 84 women with moderate-to-severe postpartum depression. The goal was to see if it reduces depressive symptoms better than a low-dose comparison. Results will help determine if this approach is safe and effective for new mothers.

This study looked at whether adding supervised Clinical Pilates exercise and prenatal education to standard care helps first-time pregnant women feel less depressed and have less back pain. 85 women took part, with some doing the extra program and others receiving only routine ca…

This study tested a program called the Pregnant Moms' Empowerment Program (PMEP) for pregnant women who had experienced intimate partner violence in the past year. The goal was to see if the program could improve mothers' mental health, reduce the chance of further violence, and …

This study tested a new medicine called SAGE-547 in 138 women with severe postpartum depression. The drug was given as a 60-hour IV infusion to see if it could quickly reduce depression symptoms compared to a placebo. The goal was to help new mothers feel better within days, with…

This study tested a free chatbot called Rosie that gives pregnant women and new moms instant, reliable health information from trusted sources. 400 minority women who were pregnant or had an infant under 6 months used the chatbot to ask questions and get answers. The goal was to …

This study tested a simple program to help new mothers who are at higher risk for health problems after giving birth. 220 Black mothers who delivered at the Hospital of the University of Pennsylvania took part. Some received a helpful pamphlet and a patient navigator they could c…

This study tested whether adding psychodramatic role-playing to standard childbirth classes could reduce postpartum depression and improve self-confidence and social support in first-time mothers. 57 pregnant women participated, with one group taking regular classes and the other…

This study looked at 74 women with a history of postpartum depression to see if mood symptoms are caused by the sudden drop in hormones after childbirth or by long exposure to those hormones. Researchers created a hormone environment similar to pregnancy and then withdrew it. The…

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…