PHARMACOKINETICS

This early-stage study tests an experimental oral drug, IPG7236, in adults with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 196 participants will take the pill tw…

This study looks at how smoking high-potency cannabis changes pain perception and feelings of a 'good drug effect' in people who use cannabis nearly every day. Researchers will also measure how long THC stays in the blood. The goal is to understand these effects both during norma…

This study looks at how antibiotics behave in the bodies of critically ill newborns, infants, and children who are on a heart-lung machine called ECMO. The goal is to see if current antibiotic doses are effective and safe. Researchers will measure drug levels in the blood to find…

This study tests two different forms of the cholesterol-lowering drug evolocumab in 400 healthy adults aged 18 to 60. The main goal is to see how the body absorbs and processes each version. Participants receive a single dose and are monitored for side effects and drug levels ove…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy adults aged 18 to 64. Participants receive one dose and are closely monitored for side effects. The study does not aim to treat any disease, but to gather important safety and…

This early-stage study in 30 healthy adults measures how the body processes oxycodone when given as a new formulation called PF614, alone or with another drug called nafamostat. The goal is to understand drug levels and safety, not to treat any condition. Results will guide futur…

This study looks at whether antibiotics given to critically ill children in the ICU reach the right levels in their blood to fight infections effectively. Researchers will measure drug concentrations after the first dose and at steady state in 640 children from newborns to age 15…

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam etzadroxil) in about 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Results will help decide if further studies are po…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing better. The goal is to improve treatme…