PHARMACOKINETICS

This early-phase study tested a new drug called boserolimab, given alone or with pembrolizumab, in 182 adults with advanced solid tumors (including lung and breast cancers). The main goals were to check safety and how the drug moves through the body. Participants received treatme…

This study tested a new method of giving the antibiotic cefoxitin to prevent infections after colorectal surgery. Instead of the standard short infusion, a pump was used to keep a steady level of the drug in the blood. The trial involved about 2,500 adults having colon or rectal …

This study tested the drug noribogaine in 55 healthy adults to learn how the body processes it and whether it is safe. Participants received either the drug or a placebo, and researchers measured drug levels in the blood over time. No treatment for any disease was given; the goal…

This study tested whether giving the drug pasireotide with a reusable pen device works as well as using a traditional syringe. Forty healthy adults received single doses by both methods. Researchers measured drug levels in the blood and checked for side effects to see if the pen …

This study looked at how the sedative drug ciprofol is processed in the body of people with moderate to severe low protein levels (hypoproteinemia). Researchers measured drug levels in the blood at different times after a single injection in 36 patients. The goal was to understan…

This study tested a computer model that helps doctors give the right dose of anti-rejection drugs to children who have had a kidney transplant. The model uses drug levels measured in the blood to predict future exposure and guide dosing. 29 children participated, and the goal was…

This study looked at how taking a new antibiotic (ceftibuten/VNRX-7145) with or without food changes the amount of drug in the blood. It involved 24 healthy adults aged 18-65. The goal was to understand the best way to take the medicine for future use.

This study tested an investigational drug called MRX1 in 20 healthy adults aged 18 to 55. The goal was to see how the body absorbs and processes the drug, check for side effects, and find out if food changes how the drug works. This is an early-phase study with no direct treatmen…

This early-stage study tested the safety and how the body processes a new drug called BB-025, which is designed to reverse the effects of another drug (BB-031). 72 healthy adults received either BB-025 or a placebo, alone or after BB-031, and were monitored for 28 days. The goal …

This study looked at how two antibiotics, ceftibuten and ledaborbactam, travel through the body and into the lungs. Thirty-four healthy adults took the drugs and had one bronchoscopy to collect lung fluid samples. The goal was to measure drug levels, not to treat any disease.

This study tested whether a new rapid-acting insulin (I004) works the same as the approved insulin NovoLog. Sixty-nine healthy volunteers received single doses of both insulins in a blinded, crossover design. The goal was to compare how the body absorbs and responds to each insul…

This early-stage study tested a vaginal ring that releases two drugs (dapivirine and levonorgestrel) in 40 healthy HIV-negative women. The goal was to measure how the body absorbs the drugs and check for safety and bleeding changes over 90 days. Results will help design future st…

This study looked at how safe kratom is and how the body processes it in healthy adults who have used opioids recreationally. Researchers gave single doses of kratom and monitored side effects and drug levels in the blood. The goal was to gather basic safety and processing inform…

This study looked at how moderate liver problems affect the way the body handles a new cancer medicine called sevabertinib. About 20 people (10 with liver impairment and 10 healthy) took a single dose and had their blood levels measured. The goal is to help doctors decide the rig…

This study looked at how a single dose of the antibiotic combination ceftibuten/VNRX-7145 moves through the body in 32 adults with normal kidney function, mild to severe kidney problems, or end-stage kidney disease on dialysis. Researchers measured drug levels in the blood and ch…

This study tested a new slow-release version of the drug pyridostigmine in 40 healthy adults. The goal was to see how the body processes the new tablet compared to the regular one, and to check for any side effects. Participants took both versions at different times so the resear…