PEDIATRIC

This study tests a drug called aficamten in children aged 12 to under 18 with a heart condition that makes it hard for blood to leave the heart. The goal is to see if the drug improves heart function and symptoms. About 55 participants will receive either aficamten or a placebo, …

This study tests whether the drug rapamycin can shrink large, hard-to-treat lymphatic malformations in the face and neck of children. About 28 kids aged 0 to 18 will take rapamycin by mouth for 6 months. The goal is to see if the malformations shrink by at least one-fifth, improv…

This study compares four different surgical methods for treating pilonidal sinus, a painful skin condition at the tailbone. Researchers will enroll 80 teens aged 12-17 to see which surgery leads to fewer complications and less pain. The goal is to find the most effective treatmen…

This study looks at whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) can provide longer and better pain relief for children after open appendix surgery. About 60 children will receive a caudal block (an injection near the tailbone) with either the combo…

This study tests a special video game controller adapter designed for children aged 7 to 17 who have one hand or arm difference. The goal is to see if the adapter makes gaming easier and more fun. Participants will try the adapter in the lab and at home for one week, then share t…

This study looks at whether a mix of two medicines (dexmedetomidine and ketamine) can safely sedate children during heart catheterization, compared to standard general anesthesia. About 150 children under 18 will take part. Researchers will check how well the sedation works and w…

This study tests whether a natural chitosan-based dressing helps children's burn wounds heal faster and with less scarring than standard silver-based dressings. About 40 children aged 6 months to 17 years with minor burns will take part. The goal is to find a better, more comfort…

This study tests whether an opioid-free anesthesia method can better control pain and agitation in children after cleft lip or palate surgery. About 90 children aged 3 months to 7 years will receive either standard opioid or opioid-free drugs. The goal is to improve recovery and …

This study is testing whether giving children a medicine called tranexamic acid during hip reconstruction surgery can reduce blood loss and the need for blood transfusions. The trial will include 400 children who are scheduled for this type of surgery. Researchers will measure bl…

This study looks at how the brain's motor network works in children with dystonia, a movement disorder. Researchers will use noninvasive tests like EEG to measure brain activity at rest and during simple tasks. The goal is to learn how the brain changes over time and how deep bra…

This study looks at a new way of providing well-child checkups for Black families. Instead of relying only on a doctor, a community health worker (called a Parent's Coach) helps with preventive care, screenings, and connecting families to resources. The goal is to see if this app…

This study looks at nerve pain in children and teens who had a limb removed before age 15-16. Researchers want to find out how common phantom or stump pain is and how it affects daily life and well-being. About 50 participants will fill out questionnaires during regular check-ups…