OSTEOGENESIS IMPERFECTA
Clinical trials for OSTEOGENESIS IMPERFECTA explained in plain language.
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New drug aims to slash fractures in brittle bone disease
Disease control OngoingThis study tests a drug called setrusumab in people with osteogenesis imperfecta (OI), a condition that causes fragile bones and frequent fractures. The goal is to see if setrusumab can lower the number of broken bones compared to a placebo. About 183 participants with OI types I…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE2, PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated May 26, 2026 04:35 UTC
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New drug aims to slash fractures in kids with brittle bones
Disease control OngoingThis study tests a drug called setrusumab in Japanese children with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. The goal is to see if it lowers the number of bone fractures, including spine fractures. Participants must have had at least one fracture in the…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated May 26, 2026 04:35 UTC
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Fetal stem cells offer hope for babies with brittle bones
Disease control OngoingThis study tests whether giving fetal stem cells to babies with severe osteogenesis imperfecta (brittle bone disease) is safe and can reduce fractures. The cells are given through a vein, either before or after birth. The trial involves 18 infants and compares them to past and cu…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE1, PHASE2 • Sponsor: Karolinska Institutet • Aim: Disease control
Last updated May 22, 2026 14:03 UTC
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New drug aims to cut fractures in kids with brittle bones
Disease control OngoingThis study tests a new medicine called setrusumab against standard bone-strengthening drugs (bisphosphonates) in children aged 2 to under 7 with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. The goal is to see if setrusumab can lower the number of broken bon…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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Invisalign offers hope for safer smiles in brittle bone disease
Symptom relief OngoingThis study tests whether Invisalign clear aligners can safely and effectively straighten teeth in people with Osteogenesis Imperfecta (OI), a condition that makes bones brittle and teeth fragile. Traditional braces can be risky for OI patients, so researchers are evaluating a les…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Baylor College of Medicine • Aim: Symptom relief
Last updated May 26, 2026 05:05 UTC
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Pee power: urine test may replace needles for brittle bone diagnosis
Knowledge-focused OngoingThis study is testing whether a urine sample can be used to identify different genetic types of osteogenesis imperfecta (OI), a rare condition that makes bones break easily. Researchers will measure specific collagen breakdown products in the urine of 25 people with OI and compar…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated May 26, 2026 05:22 UTC
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Brittle bone study aims to solve breathing mystery
Knowledge-focused OngoingThis study looks at how osteogenesis imperfecta (brittle bone disease) affects the lungs and heart. Researchers will measure lung function and use CT scans in 18 adults to find out why breathing problems are common. The goal is to better understand the disease, not to test a new …
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated May 26, 2026 05:21 UTC
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Brittle bones, broken smiles: new study looks at teeth alignment in OI
Knowledge-focused OngoingThis study looks at dental and skull problems in people with moderate to severe osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will use scans to measure teeth misalignment and neck defects in 75 participants aged 10 and older. The go…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated May 22, 2026 14:05 UTC