OSTEOGENESIS IMPERFECTA
Clinical trials for OSTEOGENESIS IMPERFECTA explained in plain language.
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New drug combo shows promise for reducing fractures in brittle bone disease
Disease control CompletedThis study tested whether a two-year course of teriparatide (a bone-building drug) followed by a single infusion of zoledronic acid (a bone-strengthening drug) could reduce fractures in adults with osteogenesis imperfecta (OI), a genetic condition causing fragile bones. 350 adult…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE4 • Sponsor: University of Edinburgh • Aim: Disease control
Last updated May 26, 2026 04:37 UTC
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New nail helps kids with brittle bones walk safely
Disease control CompletedThis study looked at how well a special nail (JuniOrtho™) works for children with osteogenesis imperfecta, a condition that makes bones very fragile. The nail is placed inside the bone to help fix fractures or straighten bones. The study included 14 children and focused on safety…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Orthofix s.r.l. • Aim: Disease control
Last updated May 22, 2026 13:50 UTC
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Gentle exercise boosts fitness in kids with brittle bones
Symptom relief CompletedThis study looked at whether a one-year, supervised adaptive physical activity program can improve aerobic capacity, cardiovascular health, bone benefits, and quality of life in children and adolescents aged 6 to 18 with osteogenesis imperfecta (brittle bone disease). Thirty part…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated May 26, 2026 05:05 UTC
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Brittle bone breakthrough? new study tracks movement to unlock disease secrets
Knowledge-focused CompletedThis study aimed to better understand osteogenesis imperfecta (brittle bone disease) by collecting information from 33 patients. Researchers used special sensors to analyze how patients walk and move, and also looked at their genetic data and quality of life. The goal was to gath…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated May 26, 2026 05:25 UTC
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Long-Term study reveals how brittle bone disease progresses over time
Knowledge-focused CompletedThis study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to learn how the condition affects the body over time. Researchers tracked bone health, lung and heart function, hearing, and movement. The goal was to better und…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated May 26, 2026 05:22 UTC
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Researchers observe bone disorders to expand medical knowledge
Knowledge-focused CompletedThis study looked at people with suspected bone-related connective tissue disorders, like Osteogenesis Imperfecta and Melorheostosis, along with their healthy family members. The goal was not to test new treatments but to better understand these conditions through exams, scans, a…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated May 26, 2026 05:05 UTC
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Scientists watch brittle bone disease in kids to unlock its secrets
Knowledge-focused CompletedThis study followed 46 children with osteogenesis imperfecta (OI), a condition that causes fragile bones and short stature, to understand how the disease progresses and how genes influence it. Participants had regular check-ups, scans, and tests over several years. No treatments …
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated May 20, 2026 11:57 UTC
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Scientists hunt for hidden switches that make brittle bones worse or milder
Knowledge-focused CompletedThis study looked at 66 adults to find small molecules called microRNAs in the blood that might explain why some people with osteogenesis imperfecta (brittle bone disease) have a mild form while others have a severe form. Researchers compared people with type 1 (mild) and type 3 …
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Apr 24, 2026 16:19 UTC