OLDER ADULTS

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study tests whether a 6-week self-management program, done with a caregiver's help, can improve diabetes control and thinking skills in older adults who have both diabetes and mild memory loss. About 309 participants aged 55 and older will take part. The program includes wee…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study looks at whether combining breathing muscle training with blood flow restriction (a technique that lightly limits blood flow to the arms or legs during exercise) is safe and helpful for frail older adults. The goal is to see if it can improve physical function, muscle …

This study tests whether a special numbing medicine (liposomal bupivacaine) injected near the hip before surgery can control pain for up to 72 hours after hip fracture surgery in people aged 55 and older. The goal is to reduce pain, lower the need for strong painkillers like opio…

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study explores whether tracking eye movements and arm motions during virtual reality driving tasks can help identify early signs of mild cognitive impairment (MCI) in older adults. Researchers will enroll 192 participants, including healthy young adults, healthy older adults…

This study aims to understand how HIV and its treatment affect aging in people 60 and older in West Africa. Researchers will compare 300 older adults with HIV to 300 without HIV to measure frailty and other age-related health issues. The goal is to improve care and develop better…

This study looks at whether a 7-week workshop program called Count Me In can improve social participation and well-being in older adults who have lost some independence. Researchers will measure loneliness, mood, thinking skills, and how often participants join in activities. The…

This study looks at whether older adults with mild memory issues are more likely to become confused after planned hip replacement surgery. Researchers will test memory before surgery and watch for confusion in the first three days after. The goal is to see if a quick memory test …