MYELOFIBROSIS，MF
Clinical trials for MYELOFIBROSIS，MF explained in plain language.
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New drug aims to reverse bone marrow scarring in rare blood cancer
Disease control Recruiting nowThis study tests if pacritinib can reduce bone marrow scarring (fibrosis) in 30 adults with myelofibrosis who also have low platelet counts. Participants take pacritinib for up to two years, and doctors check bone marrow and spleen changes using scans and biopsies. The goal is to…
Matched conditions: MYELOFIBROSIS，MF
Phase: PHASE2 • Sponsor: Grupo Español de Enfermedades Mieloproliferativas Crónicas PH Negativas • Aim: Disease control
Last updated May 26, 2026 10:56 UTC
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New combo therapy aims to shrink spleens and ease symptoms in myelofibrosis patients
Disease control Recruiting nowThis early-stage trial tests a combination of two drugs, tagraxofusp and pacritinib, in about 20 adults with myelofibrosis (a type of bone marrow cancer) who have already tried standard JAK inhibitors or cannot take them. The main goals are to see if the combo can shrink an enlar…
Matched conditions: MYELOFIBROSIS，MF
Phase: EARLY_PHASE1 • Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated May 26, 2026 10:35 UTC
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New combo therapy aims to control rare blood cancers
Disease control Recruiting nowThis study tests a new drug called axatilimab, alone and with the standard drug ruxolitinib, in people with myelofibrosis or chronic myelomonocytic leukemia. The goal is to find a safe dose and see if the combination helps control the disease. About 66 adults who have not respond…
Matched conditions: MYELOFIBROSIS，MF
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 26, 2026 10:34 UTC
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Cheap arthritis drug could be new weapon against rare blood cancers
Disease control Recruiting nowThis study tests whether low-dose methotrexate (MTX), a safe and inexpensive drug used for decades in arthritis, can help people with certain blood cancers called myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and myelofibrosis. Resea…
Matched conditions: MYELOFIBROSIS，MF
Phase: PHASE2 • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Disease control
Last updated May 26, 2026 10:34 UTC
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New hope for rare blood cancers: first human trial of PRT12396 begins
Disease control Recruiting nowThis early-stage study tests a new drug called PRT12396 in about 100 people with two rare blood cancers: polycythemia vera and myelofibrosis. The main goals are to find a safe dose and see if the drug can help control the disease. Participants must have a specific genetic mutatio…
Matched conditions: MYELOFIBROSIS，MF
Phase: PHASE1 • Sponsor: Prelude Therapeutics • Aim: Disease control
Last updated May 20, 2026 11:56 UTC
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New hope for myelofibrosis patients: drug combo trial targets those failed by standard therapy
Disease control Recruiting nowThis early-stage trial tests a new drug called roginolisib combined with the standard drug ruxolitinib in 26 adults with myelofibrosis whose disease did not respond to approved JAK inhibitors. The main goal is to check the safety and tolerability of the combination. Researchers w…
Matched conditions: MYELOFIBROSIS，MF
Phase: PHASE1, PHASE2 • Sponsor: iOnctura • Aim: Disease control
Last updated May 18, 2026 12:09 UTC
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Could a simple blood test and PET scan replace painful bone marrow biopsies for myelofibrosis patients?
Diagnosis Recruiting nowThis study aims to develop a non-invasive method to detect and track fibrosis (scarring) in myelofibrosis, a serious blood disorder. Currently, doctors must perform a bone marrow biopsy to check fibrosis. The researchers will test whether a blood test and a special PET scan can i…
Matched conditions: MYELOFIBROSIS，MF
Phase: NA • Sponsor: Azienda Ospedaliero-Universitaria di Parma • Aim: Diagnosis
Last updated May 20, 2026 11:53 UTC
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New registry aims to unlock secrets of rare blood cancers
Knowledge-focused Recruiting nowThis study is a long-term registry for people with myeloproliferative neoplasms (MPNs), a group of rare blood cancers. Researchers will collect health records, surveys, and insurance data from 5,000 participants over at least five years to understand how the disease progresses an…
Matched conditions: MYELOFIBROSIS，MF
Sponsor: MPN Research Foundation • Aim: Knowledge-focused
Last updated May 26, 2026 11:04 UTC