MUSCLE-INVASIVE BLADDER CARCINOMA

This early-stage trial tests a personalized cancer vaccine for people with bladder or gastroesophageal cancer who have tiny amounts of cancer still detectable after surgery. The vaccine is custom-made from each patient's unique tumor markers and aims to train the immune system to…

This study tests whether combining futibatinib (a targeted therapy) with durvalumab (an immunotherapy) before bladder removal surgery can help people with muscle-invasive bladder cancer who cannot receive standard cisplatin chemotherapy. About 24 participants will receive the dru…

This study tests a treatment plan for people with a type of muscle-invasive bladder cancer that has unusual cells (variant histology). Participants first receive chemotherapy with or without immunotherapy, then a combination of radiation and low-dose chemo to try to save the blad…

This study tests whether removing only the cancerous part of the bladder (partial cystectomy) plus nearby lymph nodes works as well as removing the whole bladder for muscle-invasive bladder cancer. About 40 adults with early-stage cancer that hasn't spread will get standard chemo…

This study looks at whether taking antibiotics after bladder removal surgery helps prevent urinary tract infections. About 120 adults with muscle-invasive bladder cancer will be randomly assigned to receive either an antibiotic or no antibiotic after surgery. The goal is to see i…

This early-phase study tests whether combining the drug sacituzumab govitecan with advanced radiation therapy is safe and tolerable for people with muscle-invasive bladder cancer that hasn't spread. The goal is to treat the cancer while preserving the bladder, avoiding the need f…

This study tests whether adding a new drug (fianlimab) to standard chemotherapy and immunotherapy can help adults with muscle-invasive bladder cancer achieve a complete response, meaning no cancer is found after treatment. About 36 participants will receive either the standard co…

This study tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with muscle invasive bladder cancer. The goal is to kill the cancer while allowing patients to keep their bladder, avoiding the standard surgery to remove it. Abou…

This study looks at whether placing a small tube (stent) in the ureter after bladder removal surgery reduces the risk of urinary tract infections. About 70 adults with bladder or pelvic cancer will be randomly assigned to receive a stent or not. Researchers will track infections …

This study looks at whether taking PET scans later (2.5 hours after injection) finds lymph node spread in muscle-invasive bladder cancer more accurately than standard scans (1 hour after). About 66 adults with this cancer will get both scans, and results will be compared to surgi…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of mu…

This study aims to understand the sexual health challenges and needs of bladder cancer patients, and to develop a support program. Researchers will interview 30 patients to learn about their experiences and preferences. The goal is to create a program that helps patients and thei…