Muscle-invasive bladder carcinoma
Clinical trials for Muscle-invasive bladder carcinoma explained in plain language.
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Can immunotherapy plus chemo spare bladders in cancer patients?
Disease control OngoingResearchers test whether giving nivolumab with AMVAC chemotherapy before surgery helps people with muscle-invasive bladder cancer. The trial enrolls adults with bladder cancer that has grown into the muscle wall. Some participants whose tumors shrink completely may keep their bla…
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Phase 2 • Sponsor: Fox Chase Cancer Center • Aim: Disease control
Last updated Sep 21, 2026 19:00 UTC
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Can tumor genes decide who keeps their bladder?
Disease control OngoingResearchers at Dana-Farber Cancer Institute are testing whether information from a bladder tumor's genes, combined with how the tumor responds to chemotherapy, can help doctors and patients decide between bladder-sparing chemoradiation and surgery to remove the bladder. The study…
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Early phase 1 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Immunotherapy boosts bladder cancer treatment in major trial
Disease control OngoingThis Phase III trial tests whether adding the immunotherapy drug atezolizumab to standard chemoradiotherapy helps people with muscle-invasive bladder cancer that hasn't spread. About 475 participants receive either chemoradiotherapy alone or with atezolizumab. The main goal is to…
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Phase 3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Could skipping chemo speed up bladder cancer surgery without harm?
Disease control OngoingThis phase 3 trial asks whether removing the bladder right away is as effective as giving chemotherapy first, for patients with muscle-invasive bladder cancer who have no visible tumor left after a thorough biopsy. About 236 adults will be randomly assigned to either surgery alon…
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Phase 3 • Sponsor: Regina Elena Cancer Institute • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Keytruda may let some bladder cancer patients avoid bladder removal
Disease control OngoingThis phase 2 trial is testing whether the immunotherapy drug Keytruda (pembrolizumab) can help people with muscle-invasive bladder cancer avoid having their bladder removed. About 46 participants will receive two cycles of Keytruda, then doctors will check if the cancer has compl…
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Phase 2 • Sponsor: Matthew Galsky • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New radiation technique aims to slash gut damage in bladder cancer patients
Disease control OngoingThis study tests a new type of daily radiation therapy for muscle-invasive bladder cancer that adapts to changes in the body each day. The goal is to see if this approach lowers the chance of diarrhea and other bowel problems compared to standard radiation. About 110 adults with …
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Sponsor: Varian, a Siemens Healthineers Company • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC
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New bladder cancer cocktail aims to save the bladder
Disease control OngoingThis phase 2 trial is testing whether a combination of chemotherapy, an immunotherapy drug called toripalimab, and radiation can effectively treat muscle-invasive bladder cancer while allowing patients to keep their bladder. About 71 adults with this type of bladder cancer will r…
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Bladder cancer drug combo trial pulled before it even started
Disease control CancelledThis trial was designed to test two drugs—erdafitinib and atezolizumab—for people with muscle invasive bladder cancer who cannot take the standard chemotherapy drug cisplatin. Erdafitinib targets a specific gene change that can drive cancer growth, while atezolizumab helps the im…
Matched conditions: MUSCLE-INVASIVE BLADDER CARCINOMA
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC