MUSCLE INVASIVE BLADDER CARCINOMA

This study is testing a combination of two drugs, futibatinib and durvalumab, given to patients before they have surgery to remove their bladder (cystectomy). The goal is to see if this treatment can shrink or eliminate the cancer in the bladder before it is surgically removed. I…

This study is testing the safety of combining a new, targeted cancer drug called sacituzumab govitecan with precise, image-guided radiation therapy. The goal is to control muscle-invasive bladder cancer in patients who cannot or choose not to have their bladder surgically removed…

This study is testing a treatment plan to help patients with a rare and aggressive form of bladder cancer keep their bladder. The plan involves chemotherapy, possibly with immunotherapy, followed by a combination of more chemotherapy and radiation. Researchers want to see if this…

This study is comparing two standard surgical methods for bladder cancer. It will see if patients do better with or without a temporary plastic tube (a ureteral stent) placed during surgery to remove the bladder. Researchers will track 70 patients for a year to measure complicati…

This is an early-stage safety study for a new type of personalized cancer vaccine. It is for patients with bladder or stomach cancer who have had surgery but still have tiny traces of cancer DNA in their blood, putting them at high risk for the cancer coming back. The goal is to …

This study is testing if a targeted drug called sacituzumab govitecan can help shrink tumors before surgery for patients with a rare and aggressive type of bladder cancer. The drug acts like a 'smart bomb,' attaching to cancer cells to deliver chemotherapy directly to them. The g…

This study is testing whether a combination of chemotherapy and immunotherapy can effectively treat muscle-invasive bladder cancer, with the goal of allowing patients to keep their bladder instead of needing surgery to remove it. About 36 adults with localized bladder cancer will…

This study is testing whether removing only the cancerous part of the bladder, instead of the entire bladder, is a safe and effective treatment for muscle-invasive bladder cancer. About 40 participants will receive standard chemotherapy before and after surgery, followed by the p…

This study is testing a new combination of two cancer drugs (enfortumab vedotin and pembrolizumab) given alongside targeted radiation therapy. The goal is to see if this approach can effectively control muscle-invasive bladder cancer for patients who are not candidates for, or wh…

This study is testing whether taking PET scan images 2.5 hours after injection, instead of the standard 1 hour, improves the detection of cancer spread to lymph nodes in patients with muscle-invasive bladder cancer. Researchers will compare the accuracy of the delayed images agai…

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing whether patients can safely skip taking preventive antibiotics after major surgery to remove the bladder for cancer. It compares the rate of urinary tract infections in patients who take a preventive antibiotic for 90 days after surgery versus those who take…

This study aims to create and test a counseling program to help people manage sexual health problems after bladder cancer treatment. First, researchers will interview patients to understand their specific challenges and what kind of support they want. Then, they will test if the …