METHAMPHETAMINE USE DISORDER

This study tests whether a long-term, high-dose prescription stimulant (lisdexamfetamine) can help people with moderate to severe methamphetamine use disorder stay in treatment and reduce use. About 80 participants will receive either the drug or a placebo alongside standard care…

This study tests a new type of brain stimulation (rTMS) that targets two brain areas at once to help people with methamphetamine addiction. Researchers want to see if it can reduce cravings and improve flexible thinking. 70 adults with severe methamphetamine use disorder will rec…

This early-stage study tests whether pentoxifylline, a drug that reduces inflammation, can lessen the rewarding effects of cocaine. About 30 adults with cocaine use disorder who are not seeking treatment will take part. Researchers will measure how often participants choose cocai…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with moderate to severe methamphetamine use disorder. The goal is to see if this faster treatment is safe and can help reduce meth use and cravings. Twenty participants will receive either …

This small pilot study tests whether a combination of transcranial magnetic stimulation (a non-invasive brain stimulation technique) and a mental exercise called episodic future thinking (imagining positive future events) can help people with methamphetamine use disorder. Twenty …

This early study will test whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for people trying to quit methamphetamine. Researchers will also check if it helps reduce cravings and drug use. The study involves 20 adults in Northern Louisiana who w…

This study tests a program that gives rewards (like gift cards) to people who stop using methamphetamine after a serious injury. About 40 adults who were hospitalized at a trauma center in Hawaii and tested positive for meth will join. They will visit a clinic up to three times a…

This study tests whether a non-invasive brain stimulation technique called deep TMS can help veterans reduce or stop methamphetamine use. Thirty participants will receive the treatment while researchers measure brain activity and drug use. The goal is to see if targeting specific…

This study tests whether a medication called troiluzole can reduce the appeal of methamphetamine. Forty adults who use meth but are not seeking treatment will take the drug and then choose between meth and money in a lab setting. The goal is to see if troiluzole makes people less…

This study looks at heart electrical patterns in people with methamphetamine use disorder, comparing those who also develop psychosis. Researchers will measure ECG changes at the start of treatment and before discharge. The goal is to see if psychosis adds extra heart risk. About…

This study looks at whether reducing methamphetamine use, even without quitting completely, can improve health and well-being. Researchers will track 300 adults with methamphetamine use disorder over 12 weeks of treatment and 12 weeks of follow-up. The goal is to prove that less …

This study examines levels of two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with meth-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves …