METASTASIS

This early-stage trial is testing the safety of combining two drugs, atezolizumab and ONC201, for people with advanced or recurrent endometrial cancer. The study includes both obese and non-obese participants to see how body weight affects treatment. The goal is to find the best …

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two immunotherapy drugs (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them from growing back. About 46 adults with cancer that has spread to the brain will take part. The goal is to improve tumor control, not to cure the disease…

This study tests a new drug called ifinatamab deruxtecan (I-DXd), given alone or with other treatments, for men with metastatic castration-resistant prostate cancer (mCRPC) that has stopped responding to standard hormone therapy. About 360 participants will join to find safe dose…

This study is testing a personalized radiation approach called PULSAR for people with lung cancer or lung metastases located in the central chest area. The goal is to see if this method can safely treat these hard-to-reach tumors without losing effectiveness. About 30 adults with…

This early-phase study tests a new approach called peptide alarm therapy (PAT) given as an injection directly into tumors, along with a standard immunotherapy drug, for people with advanced solid tumors that have stopped responding to at least one prior treatment. The goal is to …

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread live longer. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will als…

This study tests a combination of two drugs, abemaciclib and bicalutamide, for people with a specific type of advanced breast cancer that has spread (metastatic). The cancer must test positive for androgen receptors and negative for HER2. The goal is to find the best dose and see…

This study tests a special dye that makes cancer cells glow in lymph nodes removed during breast cancer surgery. The goal is to quickly tell if the cancer has spread, so surgeons can remove only the affected nodes and avoid extra surgery that can cause swelling and other problems…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to only a few places. The goal is to see if treatments like radiation or surgery, along with chemotherapy, help people live longer. Researchers want to find out which patients…

This study looks at people with a rare type of small intestinal cancer that has spread and cannot be fully cured. It compares those who had surgery to remove the main tumor plus other treatments, to those who had only other treatments. The goal is to see if surgery helps people l…

This study looks at a radioactive treatment called 177Lu-PSMA-617 for men with advanced prostate cancer that has spread. Researchers want to measure how much radiation the tumor and healthy organs receive, and see if that affects how well the treatment works or causes side effect…