METABOLIC DISEASES

This study looks at whether 4 weeks of high-intensity interval training (HIIT) or time-restricted eating (TRE) can improve health markers linked to type 2 diabetes in teens and young adults with overweight or obesity. Researchers will measure weight, blood sugar, insulin, and oth…

This study tests a single dose of a gene therapy called NTLA-2001 in 60 people with a rare inherited nerve disease (ATTRv-PN). The goal is to see if it can safely reduce harmful protein buildup and slow nerve damage compared to a placebo. Participants must have a confirmed diagno…

This study is following 10,000 adults aged 18 and older to learn how muscle loss (sarcopenia), metabolic diseases, and aging are connected. Researchers will collect health data, lifestyle info, and biosamples over time. The goal is to understand how these factors together affect …

This study aims to find genetic factors that may increase the risk of gout, inflammation, and metabolic diseases like diabetes and obesity in people of Polynesian ancestry. Researchers will collect health data and blood samples from 2,750 adults in French Polynesia, including tho…

This study looks at how a person's genetic makeup influences their body's response to oral semaglutide, a medication used for type 2 diabetes. Researchers will give 125 people with normal to prediabetic blood sugar levels the drug for two weeks and measure changes in blood sugar …

This study is creating a large database of 8,000 adults with heart, kidney, or metabolic diseases (like diabetes). Researchers will collect medical records, imaging, and lab results, then follow participants for up to 5 years. The goal is to better understand these conditions and…

This study uses advanced brain scans (MRI) to look for differences in brain structure, function, and chemistry between people with metabolic diseases and healthy volunteers. Researchers will track these changes over time and see how they relate to body fat and weight. The goal is…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc inside cells and how well blood vessels work. The goal is to understand how beef's…

This study looks at how well patients with inherited metabolic diseases follow their daily oral medication plans. Researchers will survey 200 patients and their parents at Necker Hospital to measure adherence and assess disease knowledge. The goal is to see if a special education…