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Polynesian gene hunt: why do gout and diabetes strike so often?

NCT ID NCT07343336

Knowledge-focused Sponsor: Lille Catholic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at the genes of 2,750 people in French Polynesia to find out why gout, inflammation, and metabolic diseases like diabetes are common there. Participants must be of Polynesian ancestry and either have gout or be part of the general population. The goal is to discover genetic links that could lead to better treatments in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,750 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

General population group: Participants will be recruited by general practitioners or study nurses during consultations in community-based practices. The objective is to include a representative general population sample, with no specific reason for consultation required or excluded. Gout group: Patients will be recruited at the Rheumatology Clinic of the Taaone Hospital Center (CHT) in Papeete when presenting with gout symptoms, either tophaceous gout or an acute flare within the previous 48 hours. 2021 follow-up group: Participants from the TOPATA study conducted in 2021 will be recontacted by telephone to assess willingness to participate, followed by an in-person inclusion visit. Only individuals currently living in Tahiti will be contacted. Nurses will be responsible for recruitment, biological sample collection, physical measurements, and questionnaire administration.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: All participants: * Age between 18 and 75 years old inclusive * Signature of informed consent * Fasting for the collection of biological samples * Declared Polynesian ancestry * Affiliated to a social security scheme General population group : * Not having participated to the 2021 TOPATA study * Visiting a general practitioner (for whatever reason) Gout Group : * Managed at the rheumatology clinic of the Taaone Hospital Centre (CHT) in Papeete by Dr Baptiste Gérard. Tophaceous gout sub-group: * Present with tophaceous gout. Gout crisis subgroup: * Be within 48 hours of the onset of a gout attack * Agree to return 1 week after inclusion for the second blood and urine sample. 2021 follow-up group: * To have been included in the TOPATA study in 2021 * Have taken the genetic and biological samples that generated the genetic and serum urate data for the 2021 study * Have hyperuricaemia without signs of gout OR without hyperuricaemia or gout at the time of inclusion in TOPATA Exclusion Criteria: All participants : * Refusal or inability to understand or give consent * Physical inability to follow and respect the protocol * 1st degree relative\*, * Person under guardianship or trusteeship * Pregnant or breast-feeding woman \* If several relatives from the same household are eligible to participate, only one person may be included in the study. The choice is left to the discretion of the investigator or the first person met. However, both members of a couple (e.g. husband and wife) may participate. * General population group : * Unable to return for sampling if required. * Gout group : * Person wearing a knee prosthesis * People suffering from other inflammatory rheumatic diseases

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Conditions

The condition(s) this trial relates to.

gout Inflammation inflammatory disease metabolic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gout disease Inflammation Metabolic diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CH de Polynesie Française Papeete

    NOT_YET_RECRUITING

    Pirae, 98716, French Polynesia

  • Medical Office Dr Antoine Scuiller

    RECRUITING

    Faa'a, 98702, French Polynesia

  • Medical Office Dr Cedric Gueguen

    RECRUITING

    Papeete, 98713, French Polynesia

  • Medical Office Dr Nanethida Nouanesengsy

    RECRUITING

    Pirae, 98716, French Polynesia

  • Medical Office Dr Raphael Habib

    RECRUITING

    Pirae, 98716, French Polynesia

  • Medical Office Dr Voradeth Nouanesengsy

    RECRUITING

    Papeete, 98714, French Polynesia

More trials for these conditions

Other studies related to the condition(s) this trial covers.