MESOTHELIOMA

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another drug (pembrolizumab), in people with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find a safe dose and see if it can shrink…

This study tests a drug called Rina-S in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to check safety and see if the drug shrinks tumors. About 764 participants with cancers like ovarian, lung, breast, or endometrial cancer will t…

This study tests whether a combination of immunotherapy drugs (durvalumab and tremelimumab) alone or with chemotherapy can help people with a type of lung cancer called pleural mesothelioma that can be removed with surgery. The goal is to see if these treatments can keep the canc…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer ce…

This study tests a drug called sacituzumab govitecan in 33 people with mesothelioma that has returned or spread after prior treatment. The goal is to see if the drug can shrink tumors and control the disease. Participants receive the drug until it stops working, side effects beco…

This early-stage trial tests an experimental drug called MRTX1719 in adults with advanced solid tumors that have a missing MTAP gene. The study aims to find a safe dose and see if the drug can shrink tumors or slow their growth. About 336 participants with cancers like mesothelio…

This study is testing an experimental drug called VT3989, taken as a pill once a day, for people with advanced solid tumors or mesothelioma that have stopped responding to standard treatments. The goal is to find safe doses and see if the drug can shrink tumors or slow cancer gro…

This early-phase study tests a new drug called NXP900 in about 140 adults with advanced solid tumors (like lung, kidney, or mesothelioma) that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors…

This early-phase trial tests a new treatment called VET3-TGI, a virus designed to infect and kill cancer cells. It is given alone or with an immunotherapy drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The main go…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This early-stage study tests a new drug called IDE892, alone or with other medicines, in people with advanced solid tumors that lack a gene called MTAP. The goal is to see if the drug is safe and can shrink tumors. About 260 adults with certain cancers (like lung, stomach, bladde…

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide treatment in real time. It includes up to 397 adults with various cancers like pancreas, lung, or prostate cancer. The goal is to see if this approach is safe and improves tumor cont…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This study tests a new drug called ODM-212 combined with other anti-cancer treatments in people with advanced solid tumors, including mesothelioma, pancreatic cancer, and non-small cell lung cancer. The trial has two parts: first finding a safe dose, then checking how well it wor…

This study is testing a new treatment that uses a radioactive substance to target and destroy cancer cells in people with advanced solid tumors (like pancreatic, stomach, or ovarian cancer) that have not responded to standard treatments. The therapy works by attaching to a protei…

This study tests a new portable chest X-ray machine that takes moving images (15 frames per second) right at the bedside in the ICU. Researchers want to see if it gives doctors better information about lung and diaphragm function compared to standard X-rays. About 230 adults with…

This study is testing whether a new PET imaging tracer called [18F]FAPI-74 can find tumors as well as or better than the standard tracer in adults with certain cancers (like pancreatic, ovarian, or lung cancer). Participants will get both types of scans to compare how many tumors…

This study tests whether giving high doses of magnesium before and during surgery can prevent kidney damage caused by the chemotherapy drug cisplatin. About 130 adults with mesothelioma will receive either magnesium or a placebo. The goal is to see if magnesium helps keep kidneys…

This study looks at whether a limited surgery to remove part of the lung lining (partial pleurectomy) can reduce symptoms and improve quality of life for people with advanced pleural mesothelioma that cannot be fully removed. About 30 participants will have the surgery and report…

This research study is collecting tissue samples from 240 adults with malignant pleural mesothelioma to test a new method that predicts how the disease will progress. The method combines molecular, radiological, and blood tests to give a score from 0 to 4. The goal is to improve …

This study is gathering health information from 12,000 adults with lung or other chest cancers. Researchers want to see how factors like genes, lifestyle, and treatments affect outcomes in everyday medical practice. No new treatments are tested—just data collected to help doctors…

This study looks at how often a specific gene change (BAP1 mutation) occurs in people with certain cancers like eye melanoma, skin melanoma, kidney cancer, and others. Researchers will study 500 patients and their family members to understand cancer patterns and risk factors. The…

This study collects blood, urine, tumor samples, and health information from up to 1,000 people with malignant mesothelioma and other cancers that express mesothelin. The goal is to build a tissue bank for future research, not to test a new treatment. Participants must be at leas…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …

This study looks at tumor samples from 220 people with pleural or peritoneal mesothelioma, a rare cancer linked to asbestos. Researchers will analyze genes and immune cells in the tumors to find patterns that predict which treatments work best. The goal is to pave the way for mor…

This study follows 800 people aged 30 and older who have or may have a BAP1 gene mutation, which raises the risk for mesothelioma and other cancers. Researchers will use advanced CT scans, blood tests, and minimally invasive cameras to find cancers earlier. The goal is to learn h…

This study follows people with inherited changes in the BAP1 gene and other cancer-related genes to learn how mesothelioma and other cancers develop. Participants include both people with mesothelioma and their family members. Researchers collect medical history, saliva, blood, a…