MALIGNANT MELANOMA

This early-phase study tests a new drug called CBA-1205, an antibody that targets a protein (DLK1) found on some cancer cells. The main goal is to check the drug's safety and find the right dose in about 66 adults with advanced solid tumors, including liver cancer and melanoma. P…

This early-stage study tests a new drug called CTX-8371 in people with advanced cancers that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. About 85 adults with certain types of lung, breast, lymphoma, head and neck,…

This study tests an experimental drug called AMT-253 in people with advanced melanoma or other solid tumors that have spread or cannot be removed. The goal is to see if the drug can shrink tumors or slow disease progression. About 96 participants will receive the drug in two phas…

This study tests a new drug called TCC1727 combined with other cancer treatments (benmelstobart, olaparib, or topotecan) in people with advanced solid tumors like lung, stomach, endometrial, or melanoma. The goal is to find the safest and most effective dose and see if the combin…

This early-phase study tests a new experimental drug (LB-LR1109) alone or combined with atezolizumab in people with advanced solid tumors, including lung, head and neck, kidney, bladder, and skin cancers. The main goals are to find safe doses and understand side effects. About 76…

This study tests whether adding a personalized mRNA vaccine (V940) to standard immunotherapy (pembrolizumab) can stop advanced melanoma from growing or spreading. About 160 people with stage III or IV melanoma that cannot be removed by surgery will receive either the vaccine plus…

This study tests a vaccine made from modified melanoma cells to help the immune system recognize and attack any remaining cancer in patients at high risk of recurrence. It is for people who have had melanoma removed and are now cancer-free or have very little disease left. The go…

This study looks at whether a 12-week supervised exercise program can reduce fatigue and improve quality of life in adults with advanced melanoma who are receiving immunotherapy or targeted therapy. About 104 participants will be randomly assigned to either an exercise group (onl…

This study tests if fecal microbiota transplantation (FMT) can help people with diarrhea and colitis caused by immune checkpoint inhibitors, a type of cancer immunotherapy. About 20 adults with melanoma or kidney cancer will receive either FMT capsules or placebo capsules alongsi…