LUNG ADENOCARCINOMA

This study tests whether the drug osimertinib can stop or shrink small, hazy lung spots (called GGNs) that remain after surgery for a type of lung cancer. About 59 adults with EGFR-mutated lung cancer will take a daily pill for a period of time. The goal is to see if the drug pre…

This early study tests whether dapagliflozin, a drug approved for diabetes and heart failure, is safe and tolerable when given before surgery to people with stage IA lung adenocarcinoma. About 48 participants will take the drug for a short time before their planned surgery. The g…

This study tests if adding a freezing procedure called cryoablation to standard immunotherapy and chemotherapy helps people with advanced lung cancer live longer. About 214 adults with metastatic lung adenocarcinoma will be split into two groups: one gets the freezing treatment p…

This study tests a new treatment for people with advanced lung cancer that cannot be removed by surgery and has stopped responding to standard therapies. The approach combines a special type of radiation that targets only the center of the tumor with an immunotherapy drug that wa…

This study looks at whether a special care plan called the Beating Lung Cancer in Ohio protocol can help people with stage IV non-small cell lung cancer live longer and feel better. It compares using targeted therapies and immunotherapies (which have fewer side effects than chemo…

This study tests a new drug called TNG260 combined with an immunotherapy (pembrolizumab) in people with advanced solid tumors that have a specific gene change (STK11 mutation). The goal is to find the safest dose and see if the combination can shrink tumors. About 126 adults with…

This study tests two ways to treat lung cancer that has spread to the brain. One group gets focused radiation plus a drug called bevacizumab; the other gets whole-brain radiation that tries to protect the memory center. The goal is to see which approach better controls the brain …

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancer. The goal is to see if it is safe and can shrink tumors. About 506 participants will take part in this early-phase trial.

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This study tests whether adding an experimental drug called TRC102 to standard treatment (chemotherapy, radiation, and immunotherapy) can better shrink tumors and extend life in people with stage III non-squamous lung cancer. TRC102 blocks cancer cells from repairing damage, maki…

This study compares two types of lung surgery for people with small lung cancers (≤2 cm). One surgery removes only a part of the lung lobe (segmentectomy), while the other removes the entire lobe (lobectomy). The goal is to see if the smaller surgery works just as well at prevent…

This study tests whether eating a special low-glucose, high-fat diet for 7 days before a PET scan can help doctors see a type of slow-growing lung cancer that often gets missed on standard scans. About 30 adults with suspected or confirmed lepidic-predominant lung adenocarcinoma …

This study tests a new PET scan tracer called Me-4FDG to see if it can find lung cancer earlier and more accurately. About 60 adults with lung nodules will get the tracer and a PET scan. The goal is to improve early diagnosis and reduce unnecessary procedures.

This study looks at whether yoga and mindfulness can improve the emotional, social, and physical well-being of people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect inflammation and gene activity. About 100 a…

This study looks at whether giving veterans with lung cancer extra support can help them feel better day-to-day. About 194 veterans will take part, and researchers will track their quality of life using surveys. The goal is to see if simple added help can make a real difference.

This observational study aims to find how common inherited gene changes are in Mexican patients with a type of lung cancer called adenocarcinoma. Researchers will collect blood samples from 332 participants to look for these genetic variants and see how they relate to patient out…

This study looks at fluid from around the lungs (pleural effusion) to find new markers that could help diagnose lung adenocarcinoma. Researchers will compare samples from 100 patients with and without cancer. The goal is to see if these markers can make diagnosis easier and more …

This study aims to create a decision aid for people with a type of lung cancer (lung adenocarcinoma) who have just had surgery. The tool will help patients and their doctors work together to decide whether to do molecular testing on the tumor. About 190 people, including patients…